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  4. ASB10 Antibody
  • 中文名稱：
    ASB10兔多克隆抗體
  • 貨號：
    CSB-PA691151
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A431 cells, Primary antibody: CSB-PA691151(ASB10 Antibody) at dilution 1/1650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ASB10
  • 別名：
    ASB10Ankyrin repeat and SOCS box protein 10 antibody; ASB-10 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human ASB10
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
  • 基因功能參考文獻：
    1. Variants in ASB10 were found to be significantly associated with sporadic POAG in the Pakistani population PMID: 26713451
    2. These findings suggested that the genes in the GLC1F locus may be associated with the pathogenesis of normal tension glaucoma. PMID: 20309402
    3. ASB10 may play a role in ubiquitin-mediated degradation pathways in tabecular meshwork cells. PMID: 23901248
    4. non-synonymous mutations in ASB10 do not cause Mendelian forms of primary open angle glaucoma PMID: 22798626
    5. Variants in ASB10 are associated with open-angle glaucoma. PMID: 22156576

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  • 相關(guān)疾病：
    Glaucoma 1, open angle, F (GLC1F)
  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=In the ciliary body, it is detected in the cytoplasm and perinuclear region of the pigmented ciliary epithelial layer. In the retina, it is detected in the nuclei of retinal ganglion cells.
  • 蛋白家族：
    Ankyrin SOCS box (ASB) family
  • 組織特異性：
    Expressed in the eye. The highest expression is observed in the iris, with moderate levels in the trabecular meshwork (TM), the lamina, and the optic nerve; slightly lower levels in the ciliary body, retina, and choroid; and very low levels in the lens.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17185

    OMIM: 603383

    KEGG: hsa:136371

    STRING: 9606.ENSP00000391137

    UniGene: Hs.647081



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