ATXN1L Antibody, Biotin conjugated
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中文名稱：
ATXN1L兔多克隆抗體, Biotin偶聯
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貨號：
CSB-PA002440LD01HU
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規格：
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其他：
產品詳情
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產品名稱：
Rabbit anti-Homo sapiens (Human) ATXN1L Polyclonal antibody
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Uniprot No.：
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基因名：
ATXN1L
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別名：
ATXN1L antibody; BOAT antibody; BOAT1Ataxin-1-like antibody; Brother of ataxin-1 antibody; Brother of ATXN1 antibody
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宿主：
Rabbit
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反應種屬：
Human
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免疫原：
Recombinant Human Ataxin-1-like protein (183-463AA)
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免疫原種屬：
Homo sapiens (Human)
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標記方式：
Biotin
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克隆類型：
Polyclonal
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抗體亞型：
IgG
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純化方式：
>95%, Protein G purified
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濃度：
It differs from different batches. Please contact us to confirm it.
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保存緩沖液：
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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產品提供形式：
Liquid
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應用范圍：
ELISA
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Protocols：
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儲存條件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶點詳情
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功能：
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development.
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基因功能參考文獻：
- The ATXN1L-CIC-ETS transcription factor axis as a mediator of resistance to MAPKi. PMID: 28178529
- Both ATXN1 and BOAT1 bind to the promoter region of Hey1 and inhibit the transcriptional output of Notch through direct interactions with CBF1, a transcription factor that is crucial for the Notch pathway. PMID: 21475249
- Boat is an in vivo binding partner of ataxin-1 whose altered expression in Purkinje cells may contribute to their degeneration in causes spinocerebellar ataxia type 1 animals PMID: 16121196
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亞細胞定位：
Nucleus. Cell projection, dendrite. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells.
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蛋白家族：
ATXN1 family
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組織特異性：
Expressed in cerebellum and cerebral cortex.
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數據庫鏈接：
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