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  4. IWS1 Antibody
  • 中文名稱：
    IWS1兔多克隆抗體
  • 貨號：
    CSB-PA822304ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: IWS1 antibody at 3.84µg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 92, 57, 70 kDa
      Observed band size: 70 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA822304ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA822304ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) IWS1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    IWS1
  • 別名：
    DKFZp761G0123 antibody; FLJ10006 antibody; FLJ14655 antibody; FLJ32319 antibody; Interacts with Spt6 antibody; iws1 antibody; IWS1 homolog antibody; IWS1-like protein antibody; IWS1_HUMAN antibody; IWS1L antibody; MGC126375 antibody; MGC126376 antibody; OTTHUMP00000162262 antibody; Protein IWS1 homolog antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein IWS1 homolog protein (570-819AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
  • 基因功能參考文獻：
    1. Altogether, these results indicate that a complex containing LEDGF/p75, Iws1, and Spt6 participates in regulating postintegration steps of HIV latency. PMID: 25590759
    2. IWS1, an RNA processing regulator, is phosphorylated by Akt3 and Akt1 at Ser720/Thr721 in lung cancer PMID: 24462114
    3. Here we report that the human homolog of Iws1, hIws1, physically interacts with protein arginine methyltransferases PRMT5 which methylates elongation factor Spt5 and regulates its interaction with RNA polymerase II. PMID: 17184735
    4. binding of Spt6 to Ser2-P RNAPII provides a cotranscriptional mechanism to recruit Iws1, REF1/Aly, and associated mRNA processing, surveillance, and export factors to responsive genes. PMID: 17234882
    5. recombinant Spt6 binds selectively to a stretch of uninterrupted consensus repeats located in the N-terminal half of the CTD and recruits Iws1 PMID: 19141475

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    IWS1 family
  • 數據庫鏈接：

    HGNC: 25467

    KEGG: hsa:55677

    STRING: 9606.ENSP00000295321

    UniGene: Hs.469879



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