Western Blot
Positive WB detected in: A549 whole cell lysate, Rat kidney tissue
All lanes: LGALS12 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38, 32, 37, 30, 36 kDa
Observed band size: 38 kDa
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA846606LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA846606LA01HU at dilution of 1:100
LGALS12 polyclonal antibody CSB-PA846606LA01HU was produced in the rabbit immunized by using the Recombinant Human Galectin-12 protein (1-336AA) as the immunogen. The target protein LGALS12, a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. It can bind lactose and May participate in the apoptosis of adipocytes. The related mouse protein is a primary regulator of the early stages of adipose tissue development.
This Rabbit anti-Homo sapiens (Human) LGALS12 Polyclonal antibody was tested in the ELISA, WB and IHC applications. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It reacts with the LGALS12 proteins of human or rat-origin and may be used to detect the endogenous levels of LGALS12 protein.
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Binds lactose. May participate in the apoptosis of adipocytes.
基因功能參考文獻(xiàn):
Galectin-12 is silenced in colorectal cancer via hypermethylation of its promoter. PMID: 29098769
Overexpression of galectin-12 contributes to a differentiation block in acute promyelocytic leukemia cells, and suppression of galectin-12 facilitates granulocytic differentiation. PMID: 27256573
Lower LGALS12 gene expression is associated with acute myeloid leukemia. PMID: 25953264
results suggest that mouse galectin-12 is a major regulator of adipose tissue development PMID: 15131127
亞細(xì)胞定位:
Nucleus.
組織特異性:
Not widely expressed. Predominantly expressed in adipose tissue.