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  4. LGALS7 Antibody
  • 中文名稱：
    LGALS7兔多克隆抗體
  • 貨號：
    CSB-PA09727A0Rb
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA09727A0Rb diluted at 1:1000 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LGALS7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LGALS7
  • 別名：
    Gal-7 antibody; GAL7 antibody; Galectin 7B antibody; Galectin-7 antibody; HKL-14 antibody; Human keratinocyte lectin 14 antibody; Keratinocyte lectin 14 antibody; Lectin galactoside binding soluble 7 antibody; Lectin; galactoside binding; soluble; 7B antibody; LEG7_HUMAN antibody; LGALS7 antibody; LGALS7A antibody; LGALS7B antibody; P53 induced protein 1 antibody; p53-induced gene 1 protein antibody; Pi7 antibody; PIG1 antibody; TP53I1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Galectin-7 protein (2-136AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，LGALS7 Antibody (CSB-PA09727A0Rb)，的標(biāo)記方式是Non-conjugated。對于LGALS7 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA09727B0Rb LGALS7 Antibody, HRP conjugated ELISA
    FITC CSB-PA09727C0Rb LGALS7 Antibody, FITC conjugated
    Biotin CSB-PA09727D0Rb LGALS7 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:1000-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
  • 基因功能參考文獻(xiàn)：
    1. Increased O-linked N-Acetyl-glucosamine (O-GlcNAc) is responsible for reduced Gal-7 expression in cultured human keratinocytes exposed to high glucose environment. PMID: 28526214
    2. We observed a significantly reduced overall survival for cases with high Gal-7 expression and a better survival for Gal-7 negative cases, when compared to cases with low expression of Gal-7. PMID: 28594391
    3. Data suggest that evaluation of galectin-7 could help guide postsurgical management for non-metastatic clear cell renal cell carcinoma (ccRCC). PMID: 27259255
    4. these findings reveal the existence of a positive self-amplification pathway that regulates intracellular gal-7 expression in breast and ovarian cancer cells. PMID: 29117220
    5. Gal-7 re-expression affects the regulation of molecular networks in cervical cancer that are involved in diverse cancer hallmarks, such as metabolism, growth control, invasion and evasion of apoptosis PMID: 27558259
    6. Measurement of scGal-7 content in tape-stripped samples was useful for the evaluation of the skin barrier function in dry skin conditions such as AD PMID: 27028525
    7. Data indicate that the galectin inhibitor specifically binds galectin-7 (hGal-7), disrupts the formation of homodimers, and inhibits the pro-apoptotic activity of hGal-7 on Jurkat T cells. PMID: 26543238
    8. Galectin-7 regulates keratinocytes proliferation and differentiation through JNK1 pathway. PMID: 26763438
    9. The assessment of a carbohydrate-recognition domain (CRD)-defective mutant form of gal-7 (R7S) showed that the ability of this protein to modulate apoptosis was independent of its CRD activity. PMID: 26168167
    10. our study validates the clinical significance of gal-7 overexpression in ovarian cancer PMID: 25277199
    11. Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells. PMID: 25367122
    12. Galectin-7 is produced by the premenstrual and menstrual endometrium, where it accumulates in menstrual fluid and likely acts as a paracrine factor to facilitate post-menstrual endometrial re-epithelialization. PMID: 24782449
    13. Understanding how these dendrimeric compounds interact with hGal-7 would help in the design of new tools to investigate the recognition of carbohydrates by lectins. PMID: 25367374
    14. galectin-7 is a potential predictive marker of chemotherapy and/or radiotherapy resistance in patients with oral squamous cell carcinoma PMID: 24515895
    15. galectin-7 may have a role in amyloidogenesis of primary localized cutaneous amyloidosis PMID: 25172508
    16. C/EBPbeta is an important mediator of galectin-7 gene activation in breast cancer cells PMID: 24789216
    17. Galectin-7 is produced by endometrial epithelium. It is elevated in the endometrium of women with history of miscarriage. We suggest that galectin-7 facilitates adhesion of embryo to endometrium. Elevated galectin-7 may result in abnormal adhesion. PMID: 24522232
    18. galectin-7 may play important roles in downregulating the functions of T lymphocytes after UVB irradiation PMID: 24134186
    19. galectin-7 has a tumor suppressive function, and that the gene is epigenetically modified by DNA methylation and significantly down-regulated in gastric cancer. PMID: 23985992
    20. Suggest that the differences in galectin-7 expression and subcellular and extracellular distribution may be crucially involved in the pathogenic process of hypertrophic scars. PMID: 23493985
    21. galectin-7 could be part of a common pathway used by mutant p53 to promote cancer progression PMID: 23967302
    22. The results indicate that lactose binding to human Gal-7 induces long-range effects (minor conformational shifts and changes in structural dynamics) throughout the protein that result in stabilization of the dimer state, with evidence for positive cooperativity. PMID: 23376190
    23. High GAL-7 expression is associated with epithelial ovarian cancer. PMID: 23564797
    24. Knocking down galectin-7 or S100A9 enhanced tumor cell invasion. PMID: 22864818
    25. Because residual cholesteatoma matrix is considered to be one of the main causes of cholesteatoma recurrence, staining with galectin-7 at the time of operation would be a promising way to facilitate complete removal of the residue PMID: 22377647
    26. Extracellular superoxide dismutase plays a role not only as a reactive oxygen species scavenger, but also as a pro-apoptotic factor via COX-2/galectin-7 pathways in the epidermis. PMID: 22251572
    27. high resolution crystal structure of Gal-7 at 1.4 A (a dimer) and its 1.7 A structure in complex with an inhibitor, a sulfur-containing 2-O-benzylphosphate galactoside, a possible antineoplastic agent PMID: 22059385
    28. Data suggest that the binding of Galectin 7 to Bcl-2 may constitute a new target for enhancing the intrinsic apoptosis pathway. PMID: 21289092
    29. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. PMID: 21677144
    30. Data show that high levels of galectin-7 expression in breast cancer cells drastically increased their ability to metastasize to lungs and bones, and were restricted to high-grade breast carcinomas. PMID: 20382700
    31. Proteomics analysis revealed that galectin-7 was highly expressed in esophageal squamous cell carcinoma and could be used as a potential biomarker. PMID: 20546628
    32. Data show that Galectine-7 gene was 8 times up-regulated in bronchial epithelial cells from asthmatic children after RSV infection in vitro and overexpressed in bronchial epithelial cells in asthma in vivo. PMID: 17044979
    33. galectin-7 increases the expression of MMP-9 through the p38 MAPK signaling pathway PMID: 19885589
    34. GAL7 is a negative growth regulator for human neuroblastoma cells. PMID: 13679866
    35. High levels of galectin 7 expression were associated with rapid recurrence rates in hypopharyngeal cancer PMID: 16788763
    36. there was no significant difference in Galectin 7 expression in thyroid tissue in thyroid cancer cases compared to non-cancer cases PMID: 18418527
    37. Gal-7 influence on differentiation in vivo, without evidence for a role in dissemination in head and neck squamous and basal cell carcinomas PMID: 19012243
    38. abnormal expression of galectin-7 in lymphoma cells is not dependent on p53, but is rather associated with DNA hypomethylation. PMID: 19596268

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  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway.
  • 組織特異性：
    Mainly expressed in stratified squamous epithelium.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6568

    OMIM: 600615

    KEGG: hsa:3963

    STRING: 9606.ENSP00000367891

    UniGene: Hs.558355



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