Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
基因功能參考文獻:
the conformational complexity of BLG protein-protein self-association and palmitic acid (PLM) or dodecyl sulfate (SDS) ligand recognition in the monomeric and dimeric state, was investigated. PMID: 27456117
The effect of beta-lactoglobulin (beta-LG) phenotype on the fatty acid composition and antioxidant capacity of milk is variable, which could partly be the result of a beta-LG phenotype x diet interaction. PMID: 26174000
LG plays a key role in enhancing immune responses by promoting cell proliferation through IgM receptor. PMID: 27957499
Interactions of LGB-A and LGB-B with sodium dodecyl sulfate, dodecyltrimethylammonium chloride and lauric acid, 12-carbon ligands possessing differently charged polar groups, were investigated.[LGB-A, LGB-B] PMID: 23784992
Data (including data from molecular dynamic simulations) suggest that -OH groups of 3-hydroxypalmitic acid and 16-hydroxypalmitic acid act as hydrogen-bond donors in a hydrophobic protein cavity of beta-lactoglobulin. [BLG, beta-lactoglobulin] PMID: 24658798
SNPs at the exon2 region of the beta-LG gene affected milk performance traits in Chinese Holstein cattle. PMID: 22097730
Rate constants (k(off)) for betaLg dimer dissociation, were estimated. PMID: 22853908
Because of a more favorable enthalpy, the dimerization equilibrium constant of beta-LG B was larger than that of beta-LG A at room temperature, while the two dimers became similarly stable at 35 degrees C. PMID: 21117642
Three single nucleotide polymorphisms change beta-LG B* gene structure and expression. PMID: 21750913
Kinetic studies of the interaction of beta-lactoglobulin with model membranes: stopped-flow CD and fluorescence studies. PMID: 20822106
multiple binding regions with a specific and different affinity for structurally different classes of hydrophobic drugs and, that bovine beta-lactoglobulin can bind and protect against low pH values various classes of drugs of pharmaceutical relevance. PMID: 19919177
Studies show that the addition of salts to water at pH 3.0 favors the dimerization of beta-lactoglobulin, and the dimer is the dominant species at 1M NaCl, 1M GuHCl, and 25 mM NaClO(4). PMID: 19241465
The stability of beta-lactoglobulin against unfolding is sharply affected by the pH of the medium: both A and B LGB variants are maximally stabilized against urea denaturation at acidic pH and against sodium dodecyl sulfate denaturation at alkaline pH. PMID: 12484782
association between single nucleotide polymorphism in the activator protein-2 binding site of the beta-lactoglobulin gene and its gene product can be explained as the result of differences in protein binding activity PMID: 12836958
In apo-beta-lactoglobulin simulations starting from the protonated crystal structure, a long-lived H-bond interaction between the protonated Glu89 and Ser116 was observed PMID: 14997570
Results suggest that the stability of beta-lactoglobulin arising from the hydrophobic effect is reduced by the C121S mutation so that unfolded or partially unfolded states are more favored. PMID: 15147215
PPIX binds a bLG site affected by the pH of the solution PMID: 16297563
Data describe the Tanford transition, a conformational change of bovine beta-lactoglobulin (betaLG) occurring at around pH 7, using heteronuclear NMR. PMID: 16368109
bovine beta-lactoglobulin (variant A) structural analysis at very low ionic strength PMID: 16540345
Comparison among the various probes shows multiple binding sites for hydrophobes are present in the native beta-lactoglobulin (BLG)and in the partially-and reversibly-modified form of BLG present in solution at neutral pH and subdenaturing temperatures. PMID: 16721656
the interaction and orientation of betaLG in association with various artificial lipid vesicles at neutral and acidic pH have been studied by use of several complementary spectroscopic techniques. PMID: 16819842
Found a C to A transversion at position 215 bp upstream of the translation initiation site (g.-215C>A)that segregated perfectly with differential phenotypic expression in a paternal half-sib family. PMID: 17033029
Beta lactoglobulin provides an example of binding with low specificity but high affinity, which may play an important role in protein-ligand and protein-protein networks. PMID: 17331535
analysis of pH-dependent conformational transitions of bovine beta-lactoglobulin monitored by heteronuclear NMR PMID: 17878316
the contributions of interface area desolvation and water immobilization accounted satisfactorily for the experimental heat capacity PMID: 17910061
Human LIMR, known to act as an endocytic receptor for lipocalin-1, also binds bovine BLG and mediates its cellular uptake. PMID: 17991420
A model reveals that one vitamin D3 molecule binds to the calyx (central internal binding-site) of beta-LG and the other binds to the surface of beta-LG between the alpha-helix and beta-strand I (external binding site). PMID: 18004750
The three-dimensional structure of BLG complexed with Ige Fab fragments provides the first insight into IgE antibody-allergen interactions at the molecular level. PMID: 18097096
In heterozygotes, beta-casein A and beta-lactoglobulin A were found at higher concentrations in milk compared with the variant encoded by the alternative allele whereas kappa-casein A and B variants were found at similar concentrations in AB heterozygotes PMID: 18363977
The extreme case of a completely dehydrated free binding site is realized for the large nonpolar binding cavity in bovine beta-lactoglobulin. PMID: 18427121
No differences were found in milk compositional characteristics among genetic variants of beta-lactoglobulin in 2 breeds of cows; no association between milk composition and beta-lactoglobulin was observed. PMID: 18474134
Noncovalent labeling with thioflavin T and 1-anilino-8-naphthalenesulfonate was used to follow the conformational changes occurring in beta-lactoglobulin during aggregation using time resolved luminescence. PMID: 18590743
the expression of soluble wild type recombinant BGL in Escherichia coli cells at about 109 mg rBLG/g wet weight cells and a comparison between the aggregation of wt BLG and its variant C121S upon intracellular expression. PMID: 18662787
DNA methylation changes in cell line from beta-lactoglobulin gene targeted fetus. PMID: 18789616
detected new polymorphisms in the beta-lactoglobulin (beta-LG) gene with significant effects on beta-LG protein concentration PMID: 19032698
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亞細胞定位:
Secreted.
蛋白家族:
Calycin superfamily, Lipocalin family
組織特異性:
Synthesized in mammary gland and secreted in milk.