The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA944715(LMNB1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA944715(LMNB1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-6: Hela cells, HT29 cells, human fetal liver tissue, 231 cells, K562 cells, human bladder transitional cell carcinoma tissue, Primary antibody: CSB-PA944715(LMNB1 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
基因功能參考文獻(xiàn):
Results show that HECW2 interacts with lamin B1 mediating its ubiquitination and proteasomal degradation. PMID: 29753763
down-regulation of Lamin B1 and up-regulation of Nephroblastoma overexpressed (NOV) are at least partially responsible for the inhibitory effect of Huaier on the proliferative and invasive capacity of SKHEP-1 cells PMID: 27503760
The aim of the present study was to elucidate the influence of LMNB1 upregulation on colon cancer cell line after treatment with 5-FU. The results indicate, that overexpression of LMNB1 induced dose-dependent cell death mainly by mitotic catastrophe pathway. PMID: 29115590
We show that epithelial cells failing to undergo proliferation arrest during TGF-beta-induced EMT sustain mitotic abnormalities due to failed cytokinesis, resulting in aneuploidy. This genomic instability is associated with the suppression of multiple nuclear envelope proteins implicated in mitotic regulation and is phenocopied by modulating the expression of LaminB1. PMID: 27926867
An upstream mutation alters LMNB1 gene expression in autosomal dominant adult-onset demyelinating leukodystrophy. PMID: 25701871
Deregulation of LMNB1 expression induces modified splicing of several genes, likely driven by raver-2 overexpression, and suggest that an alteration of mRNA processing could be a pathogenic mechanism in adult-onset autosomal dominant leukodystrophy. PMID: 25637521
Lamin B1 levels are increased in oligodendrocytes, the cell type that produces myelin in the central nervous system. PMID: 26311780
Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform. PMID: 25477337
LMNB1-related autosomal-dominant leukodystrophy is a slowly progressive neurological disease with survival lasting more than two decades after clinical onset. PMID: 26053668
Data indicate that lamin B1 promotes DNA double-strand breaks (DSBs) repair and cell survival. PMID: 25733566
maintenance of lamin B1 levels is required for DNA replication and repair through regulation of the expression of key factors involved in these essential nuclear functions PMID: 25535332
This led us to propose a model where the nucleolus has steady-state stiffness dependent on ribosome biogenesis activity and requires LaminB1 for its flexibility. PMID: 24297448
The regulation of lamin B1 is important for cellular physiology and disease.To how perturbations of lamin B1 affect cellular physiology and discuss the implications this has on senescence, HGPS and ADLD. PMID: 23873483
LMNB1 is required to maintain chromatin condensation in interphase nuclei. PMID: 24732130
Lamin B1 plays an important role in pancreatic cancer pathogenesis and is a novel therapeutic target of betulinic acid treatment. PMID: 23857605
we confirm the underlying role of lamin B1 duplication, regardless of the autonomic malfunction onset in Adult-onset autosomal dominant leukodystrophy PMID: 23681646
detailed molecular analysis of the largest collection of autosomal dominant leukodystrophy (ADLD) families studied, to date; identified the minimal duplicated region necessary for the disease, defined all the duplication junctions at the nucleotide level and identified the first inverted LMNB1 duplication PMID: 23649844
Rare variants of LMNB1 may contribute to susceptibility to neural tube defects. PMID: 23733478
lamin B1 down-regulation in senescence is a key trigger of global and local chromatin changes that impact gene expression, aging, and cancer PMID: 23934658
LMNB1 may contribute to senescence in at least two ways due to its uneven genome-wide redistribution: first, through the spatial reorganization of chromatin and, second, through gene repression. PMID: 23964094
Treating normal human fibroblasts with farnesyltransferase inhibitors causes the accumulation of unprocessed lamin B2 and lamin A and a decrease in mature lamin B1. PMID: 23475125
Results indicate that lamin B1 (LMNB1) accumulation in adult-onset autosomal dominant leukodystrophy (ADLD) is associated with Oct-1 recruitment. PMID: 23261988
LMNB1 protein levels decline in senescent human dermal fibroblasts and keratinocytes, mediated by reduced transcription and inhibition of LMNB1 messenger ribonucleic acid translation by miRNA-23a. PMID: 23439683
Lamin B1 is lost from primary human and murine cell strains when they are induced to senesce. PMID: 22496421
This study demonistrated that Adult-onset autosomal dominant leukodystrophy due to LMNB1 gene duplication. PMID: 21909802
The authors show that oxidative stress increases lamin B1 levels through p38 Mitogen Activated Protein kinase activation. PMID: 22246186
crystal structures of lamin B1 globular tail domain and coiled 2B domain, with similar folds to Ig-like domain and coiled-coil domain of lamin A. Found an extra intermolecular disulfide bond in lamin B1 coil 2B domain, which does not exist in lamin A/C. PMID: 22265972
LB1 expression in WI-38 cells decreases during cellular senescence PMID: 22155925
SNP array analysis revealed novel duplications spanning the entire LMNB1 gene in probands from each of four adult-onset autosomal dominant leukodystrophy families PMID: 21225301
Autosomal dominant leukodystrophy is the first disease that has ever been linked to lamin B1 mutations and it expands the pathological role of the nuclear lamia to include disorders of the brain. PMID: 20816241
results suggest that a LMNB1 regulatory sequence mutation underlies the variant adult-onset autosomal dominant leukodystrophy (ADLD) phenotype; adult forms of ADLD linked to 5q23 may be more heterogeneous clinically and genetically than previously thought PMID: 19961535
Proteomics identified lamin B1 as being significantly upregulated in HCC tumors and present in patients' plasma. PMID: 19522540
colocalizes with lamin B1 in the nucleoplasm and around the nuclear rim during S-phase of cells transfected with EBNA-1 in the absence of EBV plasmids. PMID: 12898336
organization of the nuclear envelope and lamina is dependent on a mechanism involving the methylation of lamin B1 PMID: 14504265
We now show that epitope masking in the nucleus is often responsible for failure to detect emerin and lamins in human, rat and pig tissues.These data suggest that different regions of the lamin B1 molecule are masked in different tissues. PMID: 16283426
Apoptotic neutrophils express lamin B1 on their surface; these cells may participate in the development of autoantibodies directed against cytoskeletal proteins, a condition frequently reported in several inflammatory diseases. PMID: 16365157
lamin B was essential for the formation of the mitotic matrix that tethers a number of spindle assembly factors; propose that lamin B is a structural component of the spindle matrix that promotes microtubule assembly and organization in mitosis PMID: 16543417
Results show that a lamin B1-containing nucleoskeleton is required to maintain RNA synthesis and that ongoing synthesis is a fundamental determinant of global nuclear architecture in mammalian cells. PMID: 18334554
Novel duplication on chromosomal band 5q23.2 in a French Canadian family with autosomal dominant leukodystrophy that supports the implication of duplicated LMNB1 as the disease-causing mutation. PMID: 19001169
duplication of the lamin B1 gene (LMNB1) has recently been described in a rare form of autosomal dominant adult-onset leukoencephalopathy. PMID: 19151023
Nudel regulates microtubule organization in part by facilitating assembly of the lamin B spindle matrix in a dynein-dependent manner. PMID: 19198602
Our work indicates that lamin B1 defects are probably not responsible for signs and symptoms resembling multiple sclerosis. PMID: 19348623
Lamin B1 maintains the functional plasticity of nucleoli. PMID: 19383719