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      3. 多克隆抗體
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      4. NAAA Antibody, FITC conjugated
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      NAAA Antibody, FITC conjugated
      
																		
					
      
					
      
						
        
							                            
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        中文名稱：
        
								
         NAAA兔多克隆抗體, FITC偶聯 
        
							
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        貨號：
        
								
         CSB-PA22919C0Rb 
        
							
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        規格：
        
								
        
									
        
										
										￥880
									
        
									
								
        
							
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      產品詳情
      
								
      
									
        
																														
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        產品名稱：
        
											
        Rabbit anti-Homo sapiens (Human) NAAA Polyclonal antibody
        
										
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        Uniprot No.：
        
											
										
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        基因名：
        
											
        NAAA
        
										
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        別名：
        
											
        Acid ceramidase like protein antibody; Acid ceramidase-like protein antibody; ASAH like protein antibody; ASAH-like protein antibody; N acylethanolamine acid amidase antibody; N acylethanolamine hydrolyzing acid amidase antibody; N acylsphingosine amidohydrolase (acid ceramidase) like antibody; N acylsphingosine amidohydrolase like antibody; N acylsphingosine amidohydrolase like protein antibody; N-acylethanolamine-hydrolyzing acid amidase subunit beta antibody; N-acylsphingosine amidohydrolase-like antibody; Naaa antibody; NAAA_HUMAN antibody; PLT antibody
        
										
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        宿主：
        
											
        Rabbit
        
										
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        反應種屬：
        
											
        Human
        
										
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        免疫原：
        
											
        Recombinant Human N-acylethanolamine-hydrolyzing acid amidase protein (29-199AA)
        
										
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        免疫原種屬：
        
											
        Homo sapiens (Human)
        
										
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        標記方式：
        
											
        FITC																						
        
										
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        克隆類型：
        
											
        Polyclonal
        
										
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        抗體亞型：
        
											
        IgG
        
										
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        純化方式：
        
											
        >95%, Protein G purified
        
										
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        濃度：
        
											
        It differs from different batches. Please contact us to confirm it.
        
										
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        保存緩沖液：
        
											
        Preservative: 0.03% Proclin 300
        Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
        
										
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        產品提供形式：
        
											
        Liquid
        
										
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        儲存條件：
        
											
        Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
        
										
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        貨期：
        
											
        Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
        
										
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        用途：
        
											
        For Research Use Only. Not for use in diagnostic or therapeutic procedures. 
        
										
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      產品評價
      
                
      
                  
        
      
                
      
                 
              
      
			 
														
																												
      
								
        
      
								
      靶點詳情
      
								
      
									
        
																				
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        功能：
        
											
        
												
        
												Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.												
        
											
        
										
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        基因功能參考文獻：
        
											
          
																								
        1. Variants a1 and a2 encoded the same full-length NAAA protein. PMID: 27693242
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        2. The results suggest that N-acylethanolamine acid amidase and protein tyrosine kinase 7 may be used as potential tissue biomarkers to avoid overtreatment of non-aggressive prostate cancer PMID: 24741114
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        3. MALDI-TOF MS analysis of the human NAAA zymogen (47.7 kDa) treated with peptide-N-glycosidase F (PNGase F) identified 4 glycosylation sites, and acid cleavage of the zymogen into alpha- and beta-subunits (14.6 and 33.3 kDa) activated the enzyme. PMID: 22040171
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        4. The level and activity of acid ceramidase in Alzheimer disease (AD) brain may play a role in controlling neuronal apoptosis and may mediate signalling pathways involved in the molecular mechanism of AD. PMID: 15610181
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        5. Asn-37, Asn-107, Asn-309, and Asn-333 are actual N-glycosylation sites. The glycosylation appeared to play an important role in stabilizing the enzyme protein. PMID: 17980170
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        6. we describe the overexpression and processing of recombinant human acid ceramidase in insect cells, its purification and characterization PMID: 18020949
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        7. These results showed that both N-acylethanolamine-hydrolysing acid amidase and fatty acid amide hydrolase are functionally active in human prostate cancer cells. PMID: 18806270
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        亞細胞定位：
        
											
        Lysosome. Membrane; Peripheral membrane protein.
        
										
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        蛋白家族：
        
											
        Acid ceramidase family
        
										
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        組織特異性：
        
											
        Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas.
        
										
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        數據庫鏈接：
        
											
        
												
        HGNC: 736
        												
        OMIM: 607469
        												
        KEGG: hsa:27163
        												
        STRING: 9606.ENSP00000286733
        												
        UniGene: Hs.437365
        
										
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