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  4. PPP1R3C Antibody
  • 中文名稱：
    PPP1R3C兔多克隆抗體
  • 貨號：
    CSB-PA030174
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    OTTHUMP00000020089 antibody; Phosphatase 1, regulatory inhibitor subunit 5 antibody; PP1 subunit R5 antibody; ppp1r3c antibody; PPP1R5 antibody; PPR3C_HUMAN antibody; Protein phosphatase 1 inhibitor 3C antibody; Protein phosphatase 1 regulatory subunit 3C antibody; Protein phosphatase 1 regulatory subunit 5 antibody; protein phosphatase 1, regulatory (inhibitor) subunit 3C antibody; Protein targeting to glycogen antibody; PTG antibody; R5 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Monkey
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PTG.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.
  • 基因功能參考文獻：
    1. PPP1R3C, a novel hypermethylated gene in colorectal cancer, may play a critical role in cancer cell growth in association with glucose levels. PMID: 25846879
    2. detection of methylation of PPP1R3C alone or in combination with EFHD1 in plasma DNA showed high sensitivity and specificity in CRC detection, and may be useful detection method for CRC, especially for early-stage CRCs. PMID: 24861485
    3. Findings suggest that variations in PTG may condition the course of Lafora disease and establish PTG as a potential target for pharmacogenetic and therapeutic approaches. PMID: 21738631
    4. Results demonstrated that HIF1 promotes glycogen accumulation through regulating PPP1R3C expression under hypoxia, which revealed a novel metabolic adaptation of cells to hypoxia. PMID: 20888814
    5. phosphorylation of R5/PTG at Ser-8 by AMPK accelerates its laforin/malin-dependent ubiquitination and subsequent proteasomal degradation, which results in a decrease of its glycogenic activity. PMID: 19171932

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  • 數據庫鏈接：

    HGNC: 9293

    OMIM: 602999

    KEGG: hsa:5507

    STRING: 9606.ENSP00000238994

    UniGene: Hs.303090



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