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  4. SH3BP2 Antibody
  • 中文名稱：
    SH3BP2兔多克隆抗體
  • 貨號：
    CSB-PA021224LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA021224LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SH3BP2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    3BP-2 antibody; 3BP2 antibody; 3BP2_HUMAN antibody; Abl SH3 binding protein 2 antibody; Cherubism antibody; CRBM antibody; CRPM antibody; FLJ42079 antibody; FLJ54978 antibody; RES4-23 antibody; SH3 domain binding protein 2 antibody; SH3 domain-binding protein 2 antibody; Sh3bp2 antibody; TNFAIP3 interacting protein 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human SH3 domain-binding protein 2 protein (165-301AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，SH3BP2 Antibody (CSB-PA021224LA01HU)，的標記方式是Non-conjugated。對于SH3BP2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA021224LB01HU SH3BP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA021224LC01HU SH3BP2 Antibody, FITC conjugated
    Biotin CSB-PA021224LD01HU SH3BP2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
  • 基因功能參考文獻：
    1. All members featured a heterozygous missense c.1244G>C; p.Arg415Pro SH3BP2 mutation PMID: 28721660
    2. The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival. PMID: 25810396
    3. A c.1244G>A (p.Arg415Gln) mutation in SH3BP2 gene causes cherubism in a Turkish family PMID: 24608212
    4. Authors conclude that a novel p.Asp419Tyr alteration in SH3BP2 to be a cherubism-causing mutation in a Turkish family. PMID: 23083484
    5. In the first family, a missense mutation Arg415Gln was found in exon 9 of SH3BP2 in all affected individuals. The unaffected individuals did not have the mutation. In the second family, a missense mutation Pro418Thr was identified in exon 9 of the SH3BP2 PMID: 22795151
    6. These results demonstrate that PARP1 regulates expression of SH3BP2. PMID: 22820184
    7. P416R mutation of 3BP2 causes the gain of function in B cells by increasing the interaction with specific signaling molecules. PMID: 21794028
    8. if a primary genetic defect is the cause for CGCG it is either located in SH3BP2 gene exons not yet related to cherubism or in a different gene. PMID: 21680150
    9. The SH-3BP-2 mutation may participate in the differentiation and maturation of osteoclast-like cells in the lesion of cherubism. PMID: 19576004
    10. over expression of SH3BP2 in RAW 264.7 cells potentiates sRANKL-stimulated phosphorylation of PLCgamma1 and PLCgamma2. PMID: 20872577
    11. No SH3BP2 gene mutation was found in PGCL. PMID: 20002873
    12. Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. PMID: 12200378
    13. 3BP2 may regulate b cell receptor-mediated gene activation through Vav proteins. PMID: 15345594
    14. Adaptor protein SH3BP2 regulates transcription factors through its tyrosine phosphorylation and SH2 domain. PMID: 15751964
    15. CD244-3BP2 association regulates cytolytic function but not IFN-gamma release PMID: 16177062
    16. no mutations...in giant cell granuloma PMID: 16713042
    17. How SH3BP2 affects leukocyte signaling and influences cherubism PMID: 16802602
    18. a novel A1517G missense mutation at the SH3BP2 gene in a Chinese family with multiple affected individuals with cherubism was identified PMID: 17147794
    19. Mutated in a rare human disease involved in cranial-facial development called cherubism, suggesting a role for 3BP2 in regulating osteoclast and hematopoietic cell function. [REVIEW] PMID: 17156730
    20. unexpected role of 3BP2 in endocytic and cytoskeletal regulation through its interaction with CIN85 and HIP-55 PMID: 17306257
    21. A new mutation in a family affected with cherubism PMID: 17321449
    22. People with Giant Cell Granuloma of the Jaw do not harbour cherubism-related germline SH3BP2 mutations. PMID: 17544554
    23. Point mutations in the SH3BP2 gene have been revealed in cherubism patients. PMID: 18596838
    24. 2 novel mutations were found; heterozygous missense mutation c.1442A>T (Q481L) in exon 11 in one sporadic case of CGCL and heterozygous germline and tumor tissue missense mutation c.320C>T (T107M) in exon 4 in one patient with cherubism. PMID: 19017279
    25. 3BP2 induces the protein complex with cellular signaling molecules through phosphorylation of Tyr(183) and SH2 domain leading to the activation of NFAT in B cells PMID: 19833725

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  • 相關疾病：
    Cherubism (CRBM)
  • 組織特異性：
    Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 10825

    OMIM: 118400

    KEGG: hsa:6452

    STRING: 9606.ENSP00000422168

    UniGene: Hs.167679



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