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        1.  Home
          2. 
					
        2. 抗體
          3. 
					
        3. 多克隆抗體
          4. 
					
        4. SYTL4 Antibody
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          中文名稱：
          
								
           SYTL4兔多克隆抗體 
          
							
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          貨號：
          
								
           CSB-PA070305 
          
							
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          規格：
          
								
          
									
          
										
										￥1090
									
          
									
								
          
							
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          其他：
          
								
          
									
								
          
							
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        產品詳情
        
								
        
									
          
																																																		
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          Uniprot No.：
          
											
										
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          基因名：
          
											
          SYTL4
          
										
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          別名：
          
											
          DKFZp451P0116 antibody; Exophilin-2 antibody; FLJ40960 antibody; Granuphilin antibody; SLP4 antibody; Synaptotagmin like 4 antibody; Synaptotagmin-like protein 4 antibody; Sytl4 antibody; SYTL4_HUMAN antibody
          
										
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          宿主：
          
											
          Rabbit
          
										
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          反應種屬：
          
											
          Human,Mouse,Rat
          
										
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          免疫原：
          
											
          Synthesized peptide derived from the Internal region of Human Granuphilin.
          
										
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          免疫原種屬：
          
											
          Homo sapiens (Human)
          
										
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          標記方式：
          
											
          Non-conjugated																						
          
										
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          抗體亞型：
          
											
          IgG
          
										
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          純化方式：
          
											
          The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
          
										
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          濃度：
          
											
          It differs from different batches. Please contact us to confirm it.
          
										
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          保存緩沖液：
          
											
          Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
          
										
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          產品提供形式：
          
											
          Liquid
          
										
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          應用范圍：
          
											
          WB, ELISA
          
										
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          推薦稀釋比：
          
											
          
												
          
													
													
          
														Application
														Recommended Dilution
													
          
																																																																	
          
														WB
														1:500-1:2000
													
          
																																																																	
          
														ELISA
														1:40000
													
          
																										          
												
          
											
          
										
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          Protocols：
          
											
										
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          儲存條件：
          
											
          Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
          
										
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          貨期：
          
											
          Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
          
										
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          用途：
          
											
          For Research Use Only. Not for use in diagnostic or therapeutic procedures. 
          
										
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        產品評價
        
                
        
                  
          
        
                
        
                 
              
        
			 
														
																												
        
								
          
        
								
        靶點詳情
        
								
        
									
          
																				
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          功能：
          
											
          
												
          
												Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner.												
          
											
          
										
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          基因功能參考文獻：
          
											
            
																								
          1. Determined the solution structure of human synaptotagmin-like protein 4 (Slp4). Through modification of cysteine residues, found Slp4 binding of two zinc atoms is required for correct folding. PMID: 28906046
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          2. Granuphilin makes granules immobile and fusion-reluctant beneath the plasma membrane. Those granuphilin-positive, docked granules release a portion of granuphilin upon fusion, and fuse at a frequency and time course similar to those of granuphilin-negative undocked granules. Granuphilin forms a 180-nm cluster at the site of each docked granule, along with granuphilin-interacting Rab27a and Munc18-1 clusters. PMID: 27032672
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          3. GLUT5 required an interaction cascade of Rab11, Myo5B, Slp4a, Munc18-2, and Vamp7 with Stx3. PMID: 26553929
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          4. Phosphatidylinositol 4,5-bisphosphate binds to the concave surface of granuphilin-C2A domain. The key residues involved in the binding were validated by mutation analysis. PMID: 25595293
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          5. the mechanisms of granuphilin plasma membrane targeting and release PMID: 24184645
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          6. Recruitment of STXBP1 by the Rab27A effector SYTL4 promotes Weibel-Palade body exocytosis. PMID: 24700782
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          7. Slp4 and Rab8 are expressed and interact in human platelets, and might be involved in dense granule release. PMID: 23140275
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          8. in insulin-producing cells adequate levels of mir-9 are mandatory for maintaining appropriate Granuphilin levels and optimal secretory capacity PMID: 16831872
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          9. Synaptotagmin-like protein 4 (Slp4)/granuphilin-a contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp4 specifically and directly binds the GTP-bound form of Rab3A, Rab8, and Rab27A. PMID: 11773082
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          亞細胞定位：
          
											
          Membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein.
          
										
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          數據庫鏈接：
          
											
          
												
          HGNC: 15588
          												
          OMIM: 300723
          												
          KEGG: hsa:94121
          												
          STRING: 9606.ENSP00000263033
          												
          UniGene: Hs.592224
          
										
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