Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Partial UMPS-deficiency should be included in the differential diagnosis of mild orotic aciduria. PMID: 28205048
The UMPS 638 CC genotype might be a candidate biomarker predicting toxicity in patients receiving tegafur-uracil/leucovorin-based preoperative chemoradiation for locally advanced rectal cancer PMID: 28347333
OPRT transition state analogues identify crucial components of potent inhibitors targeting OPRT enzymes. PMID: 24158442
The observed mutations, aberrant splicing and downregulation of UMPS represent novel mechanisms for acquired 5-FU resistance in colorectal cancer PMID: 22249354
[review] It is confirmed that the type I defect in hereditary orotic aciduria is caused by loss of uridine monophosphate (UMP)synthase activity PMID: 19562503
OPRT expression in colorectal carcinoma tissues is not correlated with the toxicity of 5-FU, but OPRT expression in the normal tissues can help predict the toxicity associated with 5-FU. PMID: 22931617
Although no association was detected between UMPS variants and gastrointestinal cancer risk in Caucasians, polymerase chain reaction-RFLP with BsrI digestion and DHPLC set up at 59 degrees C are reliable and cost-effective methods to genotype UMPS. PMID: 21631301
novel phosphoribosyltransferase transition states PMID: 20527751
orotate phosphoribosyl transferase/DPD ratio has a relation to cancer staging and survival rate. PMID: 20647710
Increased orotate phosphoribosyltransferase expression is associated with bladder cancers. PMID: 20112501
expression of OPRT gene and the OPRT/dihydropyrimidine dehydrogenase ratio might be useful as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer PMID: 14562021
thymidylate synthase and orotate phosphoribosyl transferase, but not dihydropyrimidine dehydrogenase, are more highly expressed in prostate cancer than in benign prostatic hyperplasia PMID: 15999119
orotate phosphoribosyl transferase has a role in lymph node metastasis of gastric cancer PMID: 16142362
The investigated SNPs of OPRT may have no major influence on 5-FU sensitivity. PMID: 16328050
The OPRT Gly213Ala polymorphism seems to be a useful marker for predicting toxicity to bolus 5-FU chemotherapy. PMID: 16818689
Overexpression of the OPRT gene plays an important role in the antiproliferative effect of 5-FU. PMID: 17237621
High expression of OPRT is associated with the response to adjuvant chemotherapy in human pancreatic cancer PMID: 17549346
data suggest that OPRT is involved in early events of pancreatic and gallbladder carcinogenesis and invasion of hepatocellular carcinomas PMID: 17607371
decreased the sensitivities of the cultured tumor cells to 5-FU. These results suggest that the OPRT expression level in tumors is an additional determinant of the efficacy of 5-FU. PMID: 17854773
OPRT activity levels in tumor tissue may be prognostic factor for survival in colorectal carcinoma with radical resection and 5-FU chemotherapy;postoperative survival was significantly better in patients with high OPRT activity PMID: 18597678
determination of OPRT levels in gastric carcinoma tissue enables to predict the response to S-1-based neoadjuvant/adjuvant chemotherapy PMID: 18633253
orotate phosphoribosyltransferase is involved in the invasion and metastasis of colorectal carcinoma PMID: 18949394
decreased activity of OPRT plays an important role in the acquired resistance of gastric cancer cells towards 5-FU PMID: 19020740
head & neck, gastric, colorectal, breast, lung & pancreatic cancer were examined; findings show mRNA expression & protein level of thymidylate synthase, dihydropyrimidine dehydrogenase & orotate phosphoribosyltransferase differed according to cancer type PMID: 19020767
Immunohistochemical staining for Orotate phosphoribosyl transferase (OPRT)revealed strong expression of OPRT in prostate cancer cells. There was a significant correlation between OPRT mRNA expression levels and the tumor pathological grade PMID: 19082440
High orotate phosphoribosyltransferase gene expression is associated with complete response to chemoradiotherapy in patients with squamous cell carcinoma of the esophagus PMID: 19307741
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相關疾病:
Orotic aciduria 1 (ORAC1)
蛋白家族:
Purine/pyrimidine phosphoribosyltransferase family; OMP decarboxylase family