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  4. WFDC1 Antibody
  • 中文名稱：
    WFDC1兔多克隆抗體
  • 貨號：
    CSB-PA826787
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA826787(WFDC1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    WFDC1
  • 別名：
    Prostate stromal protein ps20 antibody; PS20 antibody; ps20 growth inhibitor antibody; WAP four disulfide core domain 1 antibody; WAP four disulfide core domain 1 homolog antibody; WAP four-disulfide core domain protein 1 antibody; Wfdc1 antibody; WFDC1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human WFDC1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Has growth inhibitory activity.
  • 基因功能參考文獻(xiàn)：
    1. Prostrate stromal 20 overexpression upregulates expression of cyclooxygenase-2 (COX-2) in LNCaP and WPMY-1 cells, and induces expression of a growth-suppressive phenotype, which inhibits proliferation of PCa cells by ps20-expressing WPMY-1 conditioned media. PMID: 27115470
    2. HIV-1 virus transfer among primary CD4+ T-lymphocytes was promoted by ectopic ps20 expression or by exogenous addition of recombinant ps20. PMID: 21545747
    3. results suggest a minor role, if any, of WFDC1 in hepatocarcinogenesis PMID: 12032731
    4. WFDC1/ps20 is down regulated but not frequently mutated in prostate cancer. It is expressed predominantly in the normal prostatic stroma. It might play a role in the maintenance of the normal extra cellular matrix milieu in the prostate. PMID: 15305342
    5. ps20 promoted HIV entry via fusion and augmented CD54 integrin expression PMID: 17942534
    6. data suggest an important role for WFDC1 in inhibiting proliferation of both tumors and senescent cells. Finally, we suggest that the downregulation of WFDC1 might serve as a biomarker for cellular transformation PMID: 18842679
    7. suggests that the tumor suppressive function of WFDC1 may be partially a result of up-regulated Dkk1 gene expression, which is known to be a potent inhibitor of the Wnt signaling pathway PMID: 19488830
    8. our data suggest an important role for WFDC1 in inhibiting proliferation of both tumors and senescent cells PMID: 18842679

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  • 亞細(xì)胞定位：
    Secreted.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15466

    OMIM: 605322

    KEGG: hsa:58189

    STRING: 9606.ENSP00000219454

    UniGene: Hs.36688



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