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  4. notch1a Antibody
  • 中文名稱：
    notch1a兔多克隆抗體
  • 貨號：
    CSB-PA015949LA01DIL
  • 規格：
    ￥440
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) notch1a Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    notch1a
  • 別名：
    notch1a antibody; notch antibody; Neurogenic locus notch homolog protein 1 antibody; Notch 1) [Cleaved into: Notch 1 extracellular truncation antibody; NEXT); Notch 1 intracellular domain antibody; NICD)] antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Zebrafish
  • 免疫原：
    Recombinant Zebrafish Neurogenic locus notch homolog protein 1 protein (21-338AA)
  • 免疫原種屬：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，notch1a Antibody (CSB-PA015949LA01DIL)，的標記方式是Non-conjugated。對于notch1a Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA015949LB01DIL notch1a Antibody, HRP conjugated ELISA
    FITC CSB-PA015949LC01DIL notch1a Antibody, FITC conjugated
    Biotin CSB-PA015949LD01DIL notch1a Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
  • 基因功能參考文獻：
    1. Results suggest that Notch signaling regulates glycolysis-related gene expression in a context-dependent manner in neural tissues at different developmental stages. PMID: 29913146
    2. Notch signalling strength is quantitatively interpreted in different organ systems, and suggest a role for intercellular communication in regulating the output period of the segmentation clock by altering its spatial pattern. PMID: 27302627
    3. Results indicate that Jagged-Notch signaling is required for segregation between wt1-expressing cells and differentiated steroidogenic tissue. PMID: 29029162
    4. Notch pathway activation and artery formation are integrated during angiogenesis to limit angiogenesis via control of artery formation. PMID: 28714969
    5. a highly dynamic endocardium in the regenerating zebrafish heart, with two key endocardial players, Serpine1 and Notch signalling, regulating crucial regenerative processes, is reported. PMID: 28242613
    6. Appb-regulated neurogenesis is mediated through balancing the Notch1a signaling pathway and has roles in the development of the Mauthner cell PMID: 26994945
    7. Notch1 activation induces expression of ephrin b2a (efnb2a) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch activation in the absence of cardiac contraction rescues efnb2a and nrg1 expression PMID: 26628092
    8. Data show that angiopoietin-like proteins zangptl1 and 2 are required for definitive HSPCs formation, and genetically interact with notch receptor. PMID: 25714926
    9. Sara and Notch are both essential for cell fate assignation within asymmetric lineages during spinal cord neurogenesis. PMID: 25706234
    10. Notch1a and Notch1b, are each required intrinsically to fate hematopoietic stem cells (HSCs), just prior to their emergence from aortic hemogenic endothelium. PMID: 25230933
    11. 90 % of proliferating radial glia express notch1a, notch1b and notch3. In contrast, the proliferating non-glial populations of the dorsal telencephalon and hypothalamus rarely express notch3 and about half express notch1a/1b. PMID: 24039926
    12. entrainment of intracellular clocks by periodic activation of the Notch pathway is the mechanism maintaining cell synchrony during somitogenesis. PMID: 24715465
    13. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch signaling PMID: 24309209
    14. Ablation of xanthophores in yellow stripes induced melanophore death in black stripes, suggesting that melanophores require a survival signal from distant xanthophores. DeltaC and notch1a were expressed by xanthophores and melanophores, respectively. PMID: 24306107
    15. Notch signalling maintains blastema cells in a plastic, undifferentiated and proliferative state, an essential requirement for fin regeneration. PMID: 23344707
    16. Notch signaling activity maintains blastemal cells in a proliferative state and thus coordinates proliferation with differentiation during regenerative growth. PMID: 23462472
    17. knockdown of Notch1a is sufficient to rescue both the proliferative and differentiation defects in Id2a-deficient retinae PMID: 22981606
    18. A master role for Notch signaling in vertebrate mast cell development which establishes developmental origins of this lineage. PMID: 22368273
    19. her8a is positively regulated by Su(H)-dependent Notch signaling as revealed by a Notch-defective mutant and injection of variants of the Notch intracellular regulator, Su(H). PMID: 21541299
    20. Data show that inhibition or targeted knockdown of Notch signaling significantly increased clusterin mRNA expression in choroid plexus. PMID: 21385939
    21. Data show that the d-Asb11 cullin box is required for both canonical Notch signaling and proper neurogenesis. PMID: 21124961
    22. notch has a role in zebrafish intrahepatic biliary development PMID: 20108354
    23. Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions PMID: 20573700
    24. NLK negatively regulates Notch-dependent transcriptional activation by phosphorylating Notch1ICD. Phosphorylated Notch1ICD is impaired in its ability to form a transcriptionally active ternary complex. PMID: 20118921
    25. mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalization; mib is essential for efficient activation of Notch signaling by Delta PMID: 12530964
    26. Results suggest that Delta/D-Notch 1a signaling is required for spinal cord oligodendrocyte specification. PMID: 12835391
    27. role for the Notch signaling pathway in the activation of the heart regenerative response PMID: 12909711
    28. Mutations in the zebrafish deadly seven/notch1a (des) gene result in supernumerary Mauthner cells and demonstrate plasticity in the formation of the escape-response circuit PMID: 12954879
    29. Notch activation couples the regulation of location and differentiation in hindbrain boundary cells. Such coupling may be important for these cells to act as a stable signaling center. PMID: 15068793
    30. Notch has a role in inhibiting Ptf1 function and acinar cell differentiation PMID: 15280211
    31. gli2b expression is affected in Hedgehog and Notch signaling related mutants during zebrafish embryonic development PMID: 15614761
    32. Muller glia failed to differentiate suggesting an instructive role for Notch-Delta signaling in gliogenesis. PMID: 15680358
    33. DeltaD-Notch signalling has a role in establishing the secretory fate in the zebrafish intestine PMID: 15689380
    34. Data suggest that delta/notch- and integrinalpha5-dependent cell polarization and fibronectin matrix assembly occur concomitantly and interdependently during border morphogenesis. PMID: 15809039
    35. during late embryogenesis, neural cells that have low but functional levels of Cdkn1c, regulated by Notch activity, are specified for oligodendrocyte fate PMID: 16033893
    36. Together, our results indicate that Notch signaling regulates allocation of appropriate numbers of different midline cells by different mechanisms. PMID: 16876779
    37. Notch signaling has a role in regulating neural precursor allocation and binary neuronal fate decisions in zebrafish PMID: 17442701
    38. Notch1 transcription and activity was severely reduced in zebrafish and mouse Notch pathway mutants, suggesting that vertebrate Notch1 expression is regulated by a positive feedback loop PMID: 17685488
    39. Notch signaling is continuously required during embryogenesis to maintain radial glia, limit motor neuron formation and permit oligodendrocyte development PMID: 18627107
    40. d-Asb11 is a component in the regulation of Delta-Notch signalling, important in fine-tuning the lateral inhibition gradients between DeltaA and Notch through a cell non-autonomous mechanism. PMID: 18776899
    41. knockdown of notch3 function in notch1a mutants leads to the loss of rhombomere boundary cells and causes neuronal hyperplasia PMID: 19705151

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Notch 1 intracellular domain]: Nucleus.
  • 蛋白家族：
    NOTCH family
  • 數據庫鏈接：


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