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  4. pak-1 Antibody
  • 中文名稱：
    pak-1 Antibody
  • 貨號：
    CSB-PA619143XA01CXY
  • 規格：
    ￥880
  • 圖片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes:pak-1 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 38.3 kDa
      Observed band size: 38 kDa
      Exposure time: 10s.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Caenorhabditis elegans pak-1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    pak-1
  • 別名：
    Serine/threonine-protein kinase pak-1 (EC 2.7.11.1) (CePAK) (p21-activated kinase 1) (PAK1) pak-1 C09B8.7
  • 宿主：
    Rabbit
  • 反應種屬：
    Caenorhabditis elegans
  • 免疫原：
    Recombinant Caenorhabditis elegans pak-1 protein (293-572aa )
  • 免疫原種屬：
    Caenorhabditis elegans
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes. Involved in orientating axonal growth of HSN neurons. During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip cell (DTC) and in maintaining their sharp tapering morphology. In addition, plays a redundant role with max-2 in DTC-mediated guidance of gonad elongation. May phosphorylate mlc-4.
  • 基因功能參考文獻：
    1. FOXO-Pak1 pathway was recently shown to regulate mammalian neuronal polarity, our findings indicate that the roles of FOXO and Pak1 in neuronal migration are most likely conserved from C. elegans to higher organisms. PMID: 23994474
    2. PAK1 promotes reproduction, whereas it inactivates HSP16.2 gene and shortens lifespan. PMID: 23524941
    3. Pak-1 interacts with Wnt signaling to regulate tissue polarity and gene expression. PMID: 23019370
    4. only PAK-1 functions in the GIT/PIX/PAK pathway independently of RAC/CDC42 GTPases. PMID: 19023419
  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein. Cytoplasm. Cell projection, axon. Perikaryon.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Specifically colocalized with cdc-42 and ced-10 at all hypodermal cell boundaries during embryo elongation throughout the second phase of embryogenesis. Expressed mainly in pharyngeal muscles, the CAN neurons, motor neurons in the ventral nerve cord, seve
  • 數據庫鏈接：


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