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  4. ATAD2 Recombinant Monoclonal Antibody

ATAD2 Recombinant Monoclonal Antibody

  • 中文名稱：
    ATAD2 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA161349A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in:MCF-7 whole cell lysate(30μg), A-431 whole cell lysate(30μg)
      All lanes: Lipoma preferred partner antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 159/180 kDa
      Observed band size: 180 kDa
      Exposure time：180s
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ATAD2
  • 別名：
    ATPase family AAA domain-containing protein 2 (EC 3.6.1.3) (AAA nuclear coregulator cancer-associated protein) (ANCCA), ATAD2
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from Human ATAD2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    8B10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
  • 基因功能參考文獻：
    1. Results show that ATAD2 expression is regulated by PCAT-14 which activates Hedgehog pathway in hepatocellular carcinoma cells, depending on miR-372. PMID: 28415780
    2. BRDs are overexpressed in castration-resistant prostate cancer and that ATAD2 and BRD2 have prognostic value. PMID: 28591577
    3. a novel function of ATAD2 in cancer and for the first time identify a reader of newly synthesized histone di-acetylation-marks during replication. PMID: 27612420
    4. the simulations indicate that disorder and electrostatic steering function jointly to recruit ATAD2A to the histone core and that these fuzzy interactions may promote cooperativity between nearby epigenetic marks. PMID: 28798233
    5. this work defines Atad2 as a facilitator of general chromatin-templated activities such as transcription. PMID: 26459632
    6. ANCCA act as a potential biomarker for therapeutic strategy and prognostic prediction for squamous cell lung carcinoma. PMID: 27131099
    7. ATAD2 protein overexpression was a poor independent prognostic factor for gastric cancer patients PMID: 26527032
    8. ATAD2 protein expression may be a potential predictor of recurrence-free survival in hepatocellular carcinoma (HCC) patients after curative resection and ATAD2 may have prognostic value in patients with early stage HCC or normal serum alpha-fetoprotein level. PMID: 25687855
    9. Suppression of ATAD2 impaired the growth of HepG2 and Hep3B subcutaneous xenografts, by enhancing apoptosis and p-p53 and p-p38 levels. PMID: 26497681
    10. Data indicate that gene expression alterations in endometrial carcinoma samples with high ATPase family, AAA domain containing 2 protein (ATAD2) expression showed upregulation of several cancer-related genes including B-MYB gene. PMID: 26308378
    11. Results showed that ATPase family AAA domain-containing 2 overexpression was associated with progression and prognosis of colorectal cancer. PMID: 26819280
    12. Cervical cancer tissues may have highly expressed ATAD2. Oncogene ATAD2 may play an important role in cervical cancer proliferation, invasion and migration. PMID: 25813398
    13. We identified ANCCA protein expression as a novel independent poor prognostic indicator in endometrial carcinoma PMID: 25934333
    14. Data highlight the implication of Yta7 not only in gene expression, as expected, but also in genome organization, as a possible histone chaperone acting at boundary sites and regulating transcription. [review] PMID: 25377252
    15. Study reveals ANCCA as a key mediator of kinesin family deregulation in breast cancer and the crucial role of multiple kinesins in growth and survival of the tumor cells. PMID: 24391143
    16. Results found that ATAD2 is highly expressed in hepatocellular carcinoma tissues and could affect the expression of hedghog pathway. PMID: 24805933
    17. High expression of ATAD2 is associated with ovarian carcinomas PMID: 24761900
    18. miR-372 suppressed the expression of ATAD2, which was highly expressed in HCC and exerted a proto-oncogene effect in hepatic carcinogenesis. PMID: 24552534
    19. High ANCCA protein expression is associated with lymphatic metastasis in lung adenocarcinoma. PMID: 23775406
    20. Data indicate high ATAD2 expression is a marker of aggressive endometrial cancers, and suggest specific inhibitors of ATAD2 may have therapeutic utility in these and other MYC-dependent cancers. PMID: 23393560
    21. However, only ATAD2, and not MYC, overexpression explained the behavior of proliferation-related genes and predicted a worse prognosis independently of disease stage in a large validation cohort PMID: 22914773
    22. Data conclude that AR and E2F1 cooperation results from a chromatin looping over the ATAD2 promoter region between the ARBS and E2F1 binding site in an androgen-dependent manner PMID: 22771493
    23. Data show that that ANCCA is crucial for proliferation and survival of triple-negative/basal-like cancer cells and that it controls the expression of B-Myb and histone methyltransferase EZH2. PMID: 20864510
    24. Data report that ANCCA directly interacts with E2F1 to E2F3 in its complex with MLL and that its N terminus interacts with both the N and C termini of E2F1. PMID: 20855524
    25. Findings suggest that ANCCA plays an important role in prostate cancer by mediating specific AR functions in cancer cell survival and proliferation. PMID: 19318566
    26. ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors. PMID: 19843847
    27. ANCCA interacts with AR, required for IGF1R,IRS-2,SGK1, survivin expression and proliferation and survival of prostate cancer cells. ANCCA itself is highly induced by androgen. Its overexpression is found in prostate cancers with high Gleason scores. PMID: 19318566
    28. ANCCA associates directly with ERalpha and ACTR. It is selectively recruited to a subset of ERalpha target genes (cyclin D1, c-myc, and E2F1) and is required for their estrogen-induced expression and breast cancer cell proliferation. PMID: 17998543

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    AAA ATPase family
  • 組織特異性：
    Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.
  • 數據庫鏈接：

    HGNC: 30123

    OMIM: 611941

    KEGG: hsa:29028

    STRING: 9606.ENSP00000287394

    UniGene: Hs.370834



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