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  4. CLEC5A Recombinant Monoclonal Antibody

CLEC5A Recombinant Monoclonal Antibody

  • 中文名稱：
    CLEC5A Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA873686MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human CLEC5A with Anti-CLEC5A Recombinant Antibody

      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLEC5A (CSB-MP873686HU) at 2 μg/mL can bind Anti-CLEC5A recombinant antibody. The EC50 is 0.5964-0.6743 ng/mL.
    • The Binding Activity of Human CLEC5A with Anti-CLEC5A Recombinant Antibody

      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLEC5A (CSB-MP873686HUi4-B) at 2 μg/mL can bind Anti-CLEC5A recombinant antibody. The EC50 is 0.3246-0.4731 ng/mL.
    • The Binding Activity of Human CLEC5A with Anti-CLEC5A Recombinant Antibody

      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLEC5A (CSB-MP873686HUi4-B) at 2 μg/mL can bind Anti-CLEC5A recombinant antibody. The EC50 is 1.553-1.763 ng/mL.
    • The Binding Activity of Human CLEC5A with Anti-CLEC5A Recombinant Antibody

      Activity: CLEC5A Recombinant Monoclonal Antibody captured on Protein A Chip can bind Recombinant Human CLEC5A (CSB-MP873686HU) with an affinity constant of 0.285 nM as detected by MetaSPR Assay (WeSPRTM 200).
    • The Binding Activity of Human CLEC5A with Anti-CLEC5A Recombinant Antibody

      Activity: CLEC5A Recombinant Monoclonal Antibody captured on Protein A Chip can bind Recombinant Human CLEC5A (CSB-MP873686HUi4-B) with an affinity constant of 0.444 nM as detected by MetaSPR Assay (WeSPRTM 200).
    • Untransfected CHOK1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CLEC5A
  • 別名：
    C-type lectin domain family 5 member A (C-type lectin superfamily member 5) (Myeloid DAP12-associating lectin 1) (MDL-1), CLEC5A, CLECSF5 MDL1
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CLEC5A protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    22D7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, FC, SPR
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses.; (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP. This interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
  • 基因功能參考文獻(xiàn)：
    1. MDL-1 is mainly expressed in atherosclerotic lesional macrophages and increased macrophage MDL-1 expression is associated with early plaque progression and promotes macrophage survival. PMID: 29126450
    2. this study shows association of rs1285933 single nucleotide polymorphism in CLEC5A gene with dengue severity PMID: 28764923
    3. CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis PMID: 27033255
    4. Mannose Receptor and CLEC5A on Macrophage first attracts the Dengue Virus with high avidity, and the virus concurrently interacts with CLEC5A in close proximity to form a multivalent hetero-complex and facilitate CLEC5A-mediated signal transduction. Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex. PMID: 27832191
    5. The results suggest that CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo and may be considered a therapeutic target in combination with effective antivirals. PMID: 27795434
    6. Concordant overexpression of MDL-1 and DAP12 were correlated with increased production of proinflammatory cytokines in rheumatoid arthritis patients. PMID: 24465901
    7. Blockade of CLEC5A inhibits NLRP3 inflammasome activation and pyrotopsis in dengue-virus-infected inflammatory macrophages. Thus, DV can activate NLRP3 inflammasome via CLEC5A. PMID: 23152543
    8. No significant associations were noted between the genotypes and allele frequency of the 4 CLEC5A tSNPs between controls and Kawasaki disease patients. PMID: 22536019
    9. CLEC5A is homodimeric at the cell surface and binds to dengue virus serotypes 1-4. PMID: 21566123
    10. CLEC5A expression in monocyte/macrophage and granulocytes is regulated by PU.1. PMID: 21094529
    11. The crystal volume per unit weight (VM) was calculated to be 2.34 A3 Da-1, with nine molecules per asymmetric unit and a solvent content of 47.38%. CLEC5A plays an important role in the pathophysiology of dengue-virus-induced disease. PMID: 20057064
    12. blockade of CLEC5A-mediated signalling attenuates the production of proinflammatory cytokines by macrophages infected with Dengue virus (either alone or complexed with an enhancing antibody) PMID: 18496526

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 組織特異性：
    Highly expressed in bone marrow with lower levels in synovium, lung and bronchus. Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2054

    OMIM: 604987

    KEGG: hsa:23601

    STRING: 9606.ENSP00000449999

    UniGene: Hs.446235



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