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  4. CTNNA3 Recombinant Monoclonal Antibody

CTNNA3 Recombinant Monoclonal Antibody

  • 中文名稱：
    CTNNA3 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA148867A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: HEK293 whole cell lysate(30μg), Helawhole cell lysate(30μg), Jurkat whole cell lysate(30μg), HepG2 whole cell lysate(30μg), COLO205 whole cell lysate(30μg), PC-3 whole cell lysate(30μg)
      All lanes: Catenin alpha 3 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 100 kDa
      Observed band size: 100 kDa
      Exposure time：3min
    • IHC image of CSB-RA148867A0HU diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-RA148867A0HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Overlay Peak curve showing HepG2 cells stained with CSB-RA148867A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Catenin alpha-3 (Alpha T-catenin) (Cadherin-associated protein), CTNNA3
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from Human CTNNA3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    2D5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:50-1:200
    FC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May be involved in formation of stretch-resistant cell-cell adhesion complexes.
  • 基因功能參考文獻：
    1. Double MYH7 CTTNA3 heterozygotes showed a variable clinical expression of arrhythmogenic cardiomyopathy and hypertrophic cardiomyopathy. One carrier of double mutations in CTTNA3 and MYH7 genes did not fulfill the current diagnostic criteria for cardiomyopathy. PMID: 28699631
    2. The functional investigations might indicate involvement of alpha-T-catenin/CTNNA3 in the biology of peripheral nerve sheath tumors. PMID: 27765635
    3. CTNNA3 association with essential tremor. PMID: 27797806
    4. We conducted a meta-analysis of studies involving CHAT, TFAM, and VR22 polymorphisms and Alzheimer disease susceptibility. For TFAM and VR22, no significant association was detected in studied single-nucleotide polymorphisms (SNPs). Rs10997691 and rs7070570 of VR22 are not significantly associated with AD risk. PMID: 27272392
    5. Loss of CTNNA3 expression is associated with hepatocellular carcinoma. PMID: 26882563
    6. Among the genes replicated across the two samples (permutated p < 0.05 in both of them), CTNNA3 appeared promising. The inorganic cation transmembrane transporter activity pathway (GO:0022890) was associated with antidepressant response in both samples (p = 2.9e-5 and p = 0.001 in the Korean and STAR*D samples, respectively) PMID: 27091189
    7. Two African-ancestry specific variants were found to be significantly associated with metabolic syndrome S: SNP rs73989312[A] near CA10 that conferred increased risk; and SNP rs77244975[C] in CTNNA3 that conferred protection against this disease. PMID: 26507551
    8. CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies PMID: 26073756
    9. This study demonstrated that the copy number variations of CTNNA3 relate to opioid dependence. PMID: 25345593
    10. Copy Number Variations in CTNNA3 and RBFOX1 Associate with Pediatric Food Allergy PMID: 26188062
    11. Significant interaction with maternal CMV infection was found for rs7902091 (PSNP x CMV=7.3 x 10-7) in CTNNA3, a gene not previously implicated in schizophrenia. PMID: 23358160
    12. These results suggest aberrant Claudin 7, alpha - and beta-catenin expression and/or localisation patterns may be putative markers for distinguishing localised prostate cancer from aggressive metastatic disease when used collectively. PMID: 24358122
    13. CTNNA2 and CTNNA3 are tumor suppressor genes frequently mutated in laryngeal carcinomas. PMID: 24100690
    14. CTNNA3 is not major contributor or genetic risk factor for childhood asthma but rather influence the disease expression and response to therapy. PMID: 24407380
    15. Results suggest a causal relationship between CTNNA3 mutations and arrhythmogenic right ventricular cardiomyopathy PMID: 23136403
    16. GWAS study of diisocyanate asthma demonstrates an association between two closely linked CTNNA3 gene SNPs and diisocyanate asthma. PMID: 22977168
    17. A VE-cadherin-PAR3-alpha-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A(2)alpha in endothelial cells. PMID: 22398721
    18. Low alpha catenin is involved in colorectal cancer metastasis. PMID: 21562850
    19. Apart from the complexity of its regulation, alterations in both CTNNA3 and LRTMM3 are implicated in human disease. PMID: 21598020
    20. Our comprehensive mutation scanning did not identify any Arrhythmogenic right ventricular cardiomyopathy (ARVC) causing mutations. PMID: 21254927
    21. The risk allele (Y153H) of the preeclampsia susceptibility gene STOX1 negatively regulates trophoblast invasion by upregulation of the cell-cell adhesion protein a-T-catenin (CTNNA3). PMID: 20400461
    22. gene localized on chromosome 10q21 and is 1,776 kb in length; mutation screening of all 18 exons of the CTNNA3 gene in a family showing dilated cardiomyopathy (DCM)linkage to the 10q21-q23 locus, however, has not detected any DCM-linked CTNNA3 mutations PMID: 12596047
    23. We found no association between CTNNA3 and Alzheimer disease in subjects showing linkage to chromosome 10, nor were these SNPs associated with Abeta deposition in brain. CTNNA3 is unlikely to account for the susceptibility locus on chromosome 10 PMID: 15075440
    24. GATA-4 and MEF2C transcription factors transactivate the alphaT-catenin gene CTNNA3 in a tissue-specific manner. PMID: 15302915
    25. Dosage compensation of CTNNA3 and p57KIP2 in the placenta shares a conserved regulatory mechanism. PMID: 15533819
    26. VR22 or a nearby gene influences susceptibility to Alzheimer's disease, and the effect is dependent on APOE status PMID: 16199552
    27. This is the first study to report evidence of an association between a potentially functional, non-synonymous SNP in VR22 and the risk for Alzheimer's disease. PMID: 17209133
    28. In conclusion, monoallelic and biallelic CTNNA3 expression patterns are demonstrable in tumor bladder tissue, whereas normal cases show only biallelic expression. PMID: 17366617
    29. By providing an extra link between the cadherin-catenin complex and intermediate filaments, the binding of alphaT-catenin to plakophilin-2 is proposed to be a means of modulating and strengthening cell-cell adhesion between cardiac muscle cells. PMID: 17535849
    30. CTNNA3 may affect late-onset Alzheimer's disease through a female-specific mechanism independent of the APOE-epsilon4 allele. PMID: 17761686
    31. Results suggest that multiple genetic polymorphisms of CTNNA3 may be determinants of susceptibility to toluene diisocyanate-induced induced asthma. PMID: 19187332
    32. Alpha-T catenin gene has variants which influence Abeta42 and contribute to the previously reported linkage for plasma Abeta42 in late-onset Alzheimer's disease families. PMID: 14559775

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  • 相關疾病：
    Arrhythmogenic right ventricular dysplasia, familial, 13 (ARVD13)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Vinculin/alpha-catenin family
  • 組織特異性：
    Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle.
  • 數據庫鏈接：

    HGNC: 2511

    OMIM: 607667

    KEGG: hsa:29119

    STRING: 9606.ENSP00000362849

    UniGene: Hs.21375



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