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  4. CXCL3 Recombinant Monoclonal Antibody

CXCL3 Recombinant Monoclonal Antibody

  • 中文名稱：
    CXCL3 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA006249MA1HU
  • 規格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human CXCL3 with Anti-CXCL3 Recombinant Antibody


      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CXCL3 (CSB-MP006249HU) at 2 μg/mL can bind Anti-CXCL3 recombinant antibody. The EC50 is 9.702-11.20 ng/mL.
    • The Binding Activity of Human CXCL1 with Anti-CXCL3 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA.Immobilized Human CXCL1（CSB-MP006239HU) at 2 μg/mL can bind anti-CXCL3 recombinant antibody.The EC50 is 4.181-4.921 ng/mL.
    • The Binding Activity of Human CXCL1 with Anti-CXCL3 recombinant antibody
      Activity: CXCL3 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human CXCL1(CSB-MP006239HU) with an affinity constant of 0.143 nM as detected by MetaSPR Assay (WeSPRTM 200).
    • IHC image of CSB-RA006249MA1HU diluted at 1:50 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Anti-Human lgG, Fcy Fragment Specific labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)], CXCL3, GRO3 GROG SCYB3
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CXCL3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    2G10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, SPR
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
  • 基因功能參考文獻：
    1. CXCL3 exerts its carcinogenic potential by directly and/or indirectly regulating the downstream signaling pathways and the expression of transcription factors in PCa. PMID: 29524043
    2. Exogenous CXCL3 induced Erk1/2 and ETS1 phosphorylation and promoted CD133 expression. PMID: 27255419
    3. Our findings suggest that CXCL3 and its receptor CXCR2 are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis. PMID: 26837773
    4. results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy PMID: 24605943
    5. CXCL3 displays antimicrobial activity against E. coli and S. aureus. PMID: 12949249
    6. secreted growth-regulated oncogene chemokines, specifically GRO-gamma, in human Mesenchymal stromal cell-conditioned media have an effect on the differentiation and the function of human monocyte-derived dendritic cells. PMID: 23589610
    7. Data show that mesenchymal stem cells (MSCs) directly regulate T cell proliferation by induction of CXCL3 chemokine and its receptor, CXCR2 on the surface in T cells. PMID: 23023221
    8. demonstrates, for the first time, that BIRC3 (anti-apoptotic protein), COL3A1 (matrix protein synthesis), and CXCL3 (chemokine) were up-regulated in the thrombin-stimulated human umbilical vein endothelial cells PMID: 16356540
    9. GRO-gamma is a promising candidate for Th2-associated glomerular permeability factor in minimal change disease. PMID: 17389786
    10. Inhibition of ERK phosphorylation decreased expression of GRO3. PMID: 17466952
    11. Report gonadotropin-releasing hormone-regulated CXCL3 expression in human placentation. PMID: 19369450
    12. propose that chemokines belonging to the CXC family could play an important role in the etiology of tendon xanthoma (TX), with CXCL3 being a possible biological marker of onset and development of TX PMID: 19448742
    13. overexpression of CXCL13 in the intestine during inflammatory conditions favors mobilization of B cells and of LTi and NK cells with immunomodulatory and reparative functions. PMID: 19741597

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 數據庫鏈接：

    HGNC: 4604

    OMIM: 139111

    KEGG: hsa:2921

    STRING: 9606.ENSP00000296026

    UniGene: Hs.89690



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