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  4. Casp7 Recombinant Monoclonal Antibody

Casp7 Recombinant Monoclonal Antibody

  • 中文名稱：
    Casp7 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA124214A0MO
  • 規格：
    ￥1320
  • 圖片：
    • Overlay Peak curve showing Hela cells stained with CSB-RA124214A0MO (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20, Caspase-7 subunit p11], Casp7, Lice2 Mch3
  • 反應種屬：
    Mouse
  • 免疫原：
    A synthesized peptide derived from Mouse Casp7 protein
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    17G11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Overexpression promotes programmed cell death. Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9.
  • 基因功能參考文獻：
    1. Caspase 7 has a nonapoptic function that participates in normal spermatogenesis, but also displays apoptotic function in spermatogenic dysfunction. PMID: 26643564
    2. Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin. PMID: 26253163
    3. Optic nerve crush activated caspase-7 in retinal ganglion cells followed by cell death. Knockout of caspase-7 partially and significantly protected against ON injury-induced RGC loss. PMID: 26306916
    4. genetic loss of caspase-7 promotes solar-simulated light-induced skin carcinogenesis by blocking caspase-7-mediated cleavage of keratin-17. PMID: 26271098
    5. In vitro, with application of specific inhibitors and siRNA, AND-induced apoptosis was proven through ROS-ERK-P53-caspase 7-PARP signaling pathway PMID: 25162007
    6. The scotopic electroretinography demonstrated that the ablation of the CASP7 in T17M RHO retina leads to significant preservation of the function of photoreceptors compared to controls. PMID: 24664731
    7. Data suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices. PMID: 23713787
    8. The results indicate a non-essential apoptotic role of caspase-7 in the PEK apoptosis but suggest also possible non-apoptotic functions for caspase-7 in tooth development. PMID: 22858065
    9. host activation of caspase-7 in response to pore formation represents an adaptive mechanism by which host cells can protect membrane integrity during Listeria monocytogenes infection PMID: 22807671
    10. An apoptosis-independent regulatory role for caspase 7-mediated PARP1 cleavage in proinflammatory gene expression is discussed. PMID: 22464733
    11. Our findings demonstrate for the first time a strong correlation between caspase-7 activity, normal brain development, and apoptotic DNA fragmentation in Casp3-/- mice. PMID: 15525783
    12. Our results show that in contrast to dermal fibroblasts and cortical neurons, sympathetic neurons express no detectable levels of caspase-7. PMID: 16932756
    13. proteolytic processing of ataxin-7 by caspase-7 may contribute to SCA7 disease pathogenesis PMID: 17646170
    14. Caspase-7 was activated in the splenocytes of LPS-injected mice. CASP-7-deficient mice resist LPS-induced lymphocyte apoptosis & are protected from LPS-induced lethality independently of the excessive production of serum cytokines. PMID: 19168786
    15. results reveal a new mechanism for caspase-7 activation downstream of the Nlrc4 inflammasome and present a novel biological role for caspase-7 in host defense against Legionella pneumophila PMID: 19343209
    16. In mid-gestational wounds, activation of apoptotic pathways may be mediated through effector caspase 7 signals with inactivation of PARP. PMID: 19555972

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C14A family
  • 組織特異性：
    Highly expressed in heart, lung, liver and kidney. Low levels in spleen, skeletal muscle and testis. No expression in the brain.
  • 數據庫鏈接：


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