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  4. DLG2 Recombinant Monoclonal Antibody

DLG2 Recombinant Monoclonal Antibody

  • 中文名稱：
    DLG2 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA293528A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Overlay Peak curve showing PC-3 cells stained with CSB-RA293528A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93), DLG2
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from Human DLG2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    7E7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.
  • 基因功能參考文獻：
    1. DLG2 influenced the risk of Parkinson disease in Taiwan. PMID: 29290481
    2. Two novel promoters and coding first exons in the DLG2 gene were identified. These novel isoforms are expressed in the fetal brain. Deletions of these new elements were found associated with neurodevelopmental disorders. The work brings evidence for the lack of cross-annotation in human versus mouse reference genomes and nucleotide versus protein databases. PMID: 28724449
    3. DLG2 - novel candidate genes validated in a large case-control sample of schizophrenia. PMID: 26460480
    4. The PDZ1 domain of PSD-93 might accept peptides with larger residues at the C-terminus than that of PSD-95, for example the GluD2 C-terminal Ile versus the Val found at the C-terminus of NMDA receptors. PMID: 23519667
    5. This study showed that DLG2 is related the complex learning. PMID: 23201973
    6. Comparison of the structures of the binding cleft of PSD-93 PDZ1 with the previously reported structures of PSD-93 PDZ2 and PDZ3 as well as of the closely related human PSD-95 PDZ1 shows that they are very similar in terms of amino-acid composition PMID: 20054121
    7. Variation at the DLG2 locus contributes to maintenance of glucose homeostasis through regulation of insulin sensitivity and beta-cell function. PMID: 19931931
    8. Coexpression of Kir2.1 and PSD-93delta had no discernible effect upon channel kinetics but resulted in cell surface Kir2.1 clustering and suppression of channel internalization. PMID: 15304517
    9. identifies new isoform of DLG2 gene, which contains 3'-end exons of the known DLG2 gene along with the hypothetical gene FLJ37266; new isoform is specifically upregulated in renal oncocytoma PMID: 16640776
    10. postsynaptic density-93 and N-methyl-D-aspartate receptors subunits 2B mRNA are upregulated in temporal lobe tissue of epilepsy PMID: 17506987

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Membrane. Cell projection, axon. Perikaryon.
  • 蛋白家族：
    MAGUK family
  • 數據庫鏈接：

    HGNC: 2901

    OMIM: 603583

    KEGG: hsa:1740

    STRING: 9606.ENSP00000365272

    UniGene: Hs.367656



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