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中文名稱:EXOSC7 Recombinant Monoclonal Antibody
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貨號:CSB-RA968105A0HU
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規格:¥1320
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圖片:
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Western Blot
Positive WB detected in: A431 whole cell lysate(30μg), COLO205 whole cell lysate(30μg), HEK293 whole cell lysate(30μg), Hela whole cell lysate(30μg), HepG2 whole cell lysate(30μg), Jurkat whole cell lysate(30μg), K562 whole cell lysate(30μg)
All lanes: EXOSC7 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 32 kDa
Observed band size: 37 kDa
Exposure time:30s -
IHC image of CSB-RA968105A0HU diluted at 1:100 and staining in paraffin-embedded human stomach tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
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其他:
產品詳情
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Uniprot No.:
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基因名:EXOSC7
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別名:Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8), EXOSC7, KIAA0116 RRP42
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反應種屬:Human
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免疫原:A synthesized peptide derived from Human EXOSC7 protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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抗體亞型:Rabbit IgG
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純化方式:Affinity-chromatography
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克隆號:20D9
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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產品提供形式:Liquid
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應用范圍:ELISA, WB, IHC
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:5000 IHC 1:50-1:200 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
相關產品
靶點詳情
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功能:Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
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基因功能參考文獻:
- EXOSC7 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. PMID: 21509594
- The association of hCsl4p with the exosome is mediated by protein-protein interactions with hRrp42p and hRrp46p. PMID: 11812149
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亞細胞定位:Nucleus, nucleolus. Cytoplasm. Nucleus.
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蛋白家族:RNase PH family
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數據庫鏈接:
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