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  4. HYOU1 Recombinant Monoclonal Antibody

HYOU1 Recombinant Monoclonal Antibody

  • 中文名稱：
    HYOU1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA120604A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: U251 whole cell lysate(30μg), HepG2 whole cell lysate(30μg), MCF7 whole cell lysate(30μg), SH-SY5Y whole cell lysate(30μg)
      All lanes: HYOU1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 111 kDa
      Observed band size:150 kDa
      Exposure time：30s
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170), HYOU1, GRP170 ORP150
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from Human HYOU1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    15G4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.
  • 基因功能參考文獻：
    1. These results strongly suggest that AMPK can activate ORP150 through FOXO1 pathway and confer protection against endoplasmic reticulum stress - induced apoptosis of airway epithelial cells following exposure to cigarette smoke extract. PMID: 29448096
    2. Findings establish a general function of Grp170 during ERAD and suggest that positioning this client-release factor at the retrotranslocation site may afford a mechanism to couple client release from BiP and retrotranslocation. PMID: 27030672
    3. Data reveal that Grp170 participates in preparing mutant proinsulin for degradation while enabling wild-type proinsulin escape from the endoplasmic reticulum. PMID: 28028074
    4. High ORP150 expression is associated with thyroid cancer. PMID: 26700459
    5. Two NEFs, Grp170 and Sil1, trigger toxin release from BiP to enable successful retrotranslocation and clarify the fate of the toxin after it disengages from BiP. PMID: 25877869
    6. Grp170 induces nucleotide exchange of BiP and releases SV40 virus from BiP, promoting SV40 ER-to-cytosol transport and infection. PMID: 25653441
    7. HYOU1 also modulates vIL-6's ability to induce CCL2. PMID: 24920810
    8. Here we show that Grp170 can bind directly to a variety of incompletely folded protein substrates in the endoplasmic reticulum, and as expected for a bona fide chaperone, it does not interact with folded secretory proteins. PMID: 24327659
    9. inducible overexpression of ORP150, in ER stress conditions, exerts inhibitory effect on apoptosis and senescence in human breast carcinoma cells but not in normal fibroblasts PMID: 23757447
    10. Data indicate that Grp170 (Lhs1 ortholog) coprecipitate with alphaENaC. PMID: 23645669
    11. AICAR infusion enhanced ORP150 expression, resulting in the marked amelioration of hepatic ER stress and apoptosis PMID: 21296878
    12. Report ORP-150 levels in autopsy tissue after hypoxia/ischemia events in term neonates. PMID: 20626887
    13. ORP150 exerts cytoprotective effects in renal tubular epithelia subjected to I/R injury and suggest a key role for ER stress in the renal tubular response to acute renal failure PMID: 15240565
    14. Hypoxia results in an enhancement of ORP 150 expression in several tumour cell lines. PMID: 16543725
    15. These findings suggest that ORP150 is structurally and functionally well conserved in distant species PMID: 17131193
    16. Our observations led to the hypothesis that ORP150 protects against MPTP/MPP(+)-induced neurotoxicity, and indicate the importance of the ER environment in maintaining the nigrostriatal pathways. PMID: 17330988
    17. data indicate ORP150 inhibits oxLDL-induced apoptosis by blocking calcium signaling & apoptosis; calcium released from ER stores is inhibited by ORP150; ORP150 is expressed in advanced atherosclerotic lesions PMID: 18404158
    18. The forced expression of ORP150 highlights its new protective role against oxLDL-induced ER stress and subsequent apoptosis PMID: 19106412
    19. the increased expression of ORP150 is a factor which protects collagen against intracellular degradation induced by glucose deprivation. PMID: 19225868
    20. The ORP150-precursor peptide complex can elicit a cytotoxic T-lymphocyte response through cross-presentation, as well as the CD4-positive T cell response by dendritic cells. PMID: 19812200

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  • 亞細胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Heat shock protein 70 family
  • 組織特異性：
    Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic
  • 數據庫鏈接：

    HGNC: 16931

    OMIM: 601746

    KEGG: hsa:10525

    STRING: 9606.ENSP00000384144

    UniGene: Hs.277704



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