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  4. IL1RL2 Recombinant Monoclonal Antibody

IL1RL2 Recombinant Monoclonal Antibody

  • 中文名稱：
    IL1RL2 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA888016MA1HU
  • 規格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human IL1RL2 with Anti-IL1RL2 Recombinant Antibody

      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL1RL2 (CSB-MP888016HU) at 2 μg/mL can bind Anti-IL1RL2 recombinant antibody. The EC50 is 23.85-32.68 ng/mL.
    • The Binding Activity of Human IL1RL2 with Anti-IL1RL2 Recombinant Antibody

      Activity:IL1RL2 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Recombinant Human IL1RL2 (CSB-MP888016HU) protein with an affinity constant of 0.513 nM as detected by MetaSPR Assay (WeSPRTM 200).
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Interleukin-1 receptor-like 2 (IL-36 receptor) (IL-36R) (Interleukin-1 receptor-related protein 2) (IL-1Rrp2) (IL1R-rp2), IL1RL2, IL1RRP2
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human IL1RL2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    17E9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, SPR
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
  • 基因功能參考文獻：
    1. Endothelial cells, including dermal microvascular cells, express a functionally active IL-36 receptor. PMID: 27673278
    2. All human blood lymphocytes express IL-36R. PMID: 27269181
    3. The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R pathway may represent a novel target for therapeutic intervention. PMID: 26813344
    4. single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP. PMID: 27307043
    5. The IL36 receptor (IL1RL2) is an important mediator molecule in the inflammatory response. PMID: 27853811
    6. The ubiquitin-binding Tollip protein contributed to IL-36R signaling and increased the accumulation of both subunits of the IL-36R. PMID: 26269592
    7. IL36A-IL36R axis is modulated in patients with primary Sjogren's syndrome. PMID: 25902739
    8. Expression of IL-1Rrp2 by sone dendritic cell subsets may have an important function in the human immune response in vivo via its role in differentiation of inflammatory Th1 lymphocytes. PMID: 22144259
    9. These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID: 22315422
    10. IL-1alpha and IL-1beta gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry PMID: 16546408

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Interleukin-1 receptor family
  • 組織特異性：
    Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
  • 數據庫鏈接：

    HGNC: 5999

    OMIM: 604512

    KEGG: hsa:8808

    STRING: 9606.ENSP00000264257

    UniGene: Hs.659863



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