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  4. Il1rl2 Recombinant Monoclonal Antibody

Il1rl2 Recombinant Monoclonal Antibody

  • 中文名稱：
    Il1rl2 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA875357MA1MO
  • 規格：
    ￥1320
  • 圖片：
    • The Binding Activity of Mouse Il1rl2 with Anti-Il1rl2 Recombinant Antibody


      Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Il1rl2 (CSB-MP875357MO) at 2 μg/mL can bind Anti-Il1rl2 recombinant antibody. The EC50 is 0.6983-1.037 ng/mL.
    • The Binding Activity of Mouse Il1rl2 with Anti-IL1RL2 Recombinant Antibody

      Activity:IL1RL2 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Recombinant Mouse Il1rl2 (CSB-MP875357MO) protein with an affinity constant of 0.236 nM as detected by MetaSPR Assay (WeSPRTM 200).
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Interleukin-1 receptor-like 2 (IL-36 receptor) (Interleukin-1 receptor-related protein 2) (IL-1Rrp2) (IL1R-rp2), Il1rl2
  • 反應種屬：
    Mouse
  • 免疫原：
    Recombinant Mouse Il1rl2 protein
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    9E5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, SPR
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
  • 基因功能參考文獻：
    1. IL-36R likely contributes to acute kidney injury pathogenesis through NF-kB activity and IL-6 and TNF-a upregulation. PMID: 29241623
    2. these findings reveal a fundamental contribution for the IL-36/IL-36R axis in regulating the Treg-Th9 cell balance with broad implications for Th cell-mediated disorders, such as inflammatory bowel diseases and particularly ulcerative colitis PMID: 28327619
    3. IL-36R-deficient mice were protected from influenza virus-induced lung injury and mortality PMID: 27966554
    4. Data show that Interleukin-36 receptor (IL-36R)-deficient fibroblast-like synoviocytes (FLS) had a limited capacity to support plasma cells (PC) survival compared to wild-type FLS. PMID: 28857172
  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Interleukin-1 receptor family
  • 組織特異性：
    Expressed in bone marrow-derived dendritic cells, splenic CD4(+) T-cells, bone marrow-derived macrophages and bone marrow-derived neutrophils.
  • 數據庫鏈接：


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