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  4. KRT9 Recombinant Monoclonal Antibody

KRT9 Recombinant Monoclonal Antibody

  • 中文名稱：
    KRT9 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA182472A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate(30μg), PC-3 whole cell lysate(30μg), CACO-2 whole cell lysate(30μg), MCF7 whole cell lysate(30μg)
      All lanes: KRT9 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 62 kDa
      Observed band size: 62 kDa
      Exposure time：2min
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9), KRT9
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from Human KRT9 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6G7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly.
  • 基因功能參考文獻(xiàn)：
    1. A novel heterozygous c.1369C>T transition (p.Leu457Phe) in exon 6 of the KRT9 gene was identified in four patients in a Chinese Family with Epidermolytic Palmoplantar Keratoderma. PMID: 29719290
    2. During analyzing the sequences of KRT9 gene of a epidermolytic palmoplantar keratoderma (EPPK) pedigree, we found a new heterozygous missense mutation (488G>T) of exon 1 of KRT9 gene, which has not been reported before and does not exist in healthy individuals of the family and 100 unrelated individuals. PMID: 27726289
    3. Results identified the missense mutation KRT9 c.487C>T, as a potential causative mutation in the large Uygur family with epidermolytic palmoplantar keratoderma. PMID: 27864007
    4. KRT9 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    5. Findings suggest that dysregulated Keratin 9 expression is a consequence of Alzheimer's disease (AD). PMID: 26973255
    6. Mutational analysis revealed a T to G transition in the coding DNA sequence, designated as c.470T>G (p.Met157Arg), a missense mutation in exon 1 of KRT9 in the proband and her brother, but not in unrelated healthy controls. PMID: 24899405
    7. KRT9 gene mutation as a reliable indicator in the prenatal molecular diagnosis of epidermolytic palmoplantar keratoderma. PMID: 24862219
    8. A heterozygous missense mutation c.482A to G in the KRT9 gene. PMID: 24510562
    9. Our findings indicate that knuckle pads can be associated with epidermolytic palmoplantar keratoderma and the R163W mutation in a family with a genetic background different from that described here. PMID: 23278372
    10. We identified a novel Eidermolytic Palmoplantar Keratoderma-causing mutation located in a region of the KRT9 gene, encoding a poorly conserved region of the protein that is not routinely screened for diagnostic purposes. PMID: 23397986
    11. Data indicate that the node tumour burden could be accurately quantified based on the cytokeratin 19 (CK19) mRNA copy number. PMID: 23265708
    12. A heterozygous transversional mutation, 488G-->A, was identified in exon 1 of KRT9 gene in all patients. PMID: 22678789
    13. A substitution in arginine alters the charge and shape of KRT9 rod domain, disrupting the function of the helix initiation motif of keratins and compromising the integrity of filaments and weakening their stability in the epidermis of palms and soles. PMID: 22262370
    14. KRT9 may play a complicated role in the genesis of epidermolytic palmoplantar keratoderma with knuckle pads and camptodactyly. PMID: 21715251
    15. Study provides evidence that epidermolytic palmoplantar keratoderma in a large Chinese family may result from a novel duplication mutation (c.495_503dupCTCTTACTT) in the 1A rod domain of KRT9. PMID: 21489919
    16. identified mRNA transcripts from three genes CDSN, LOR and KRT9, showing strong over-expression in skin samples relative to samples from forensic body fluids, making them suitable markers for skin identification PMID: 21221983
    17. A c.T1206C substitution in the 2B domain of KRT 9 was identified. PMID: 20964665
    18. The affected members of all five families possess mutations in the KRT9 gene that severely affect heterodimer formation with the type II keratin partner. PMID: 19874353
    19. Genetic studies have revealed that K9 gene mutations are responsible for epodermolytic palmoplantar keratoderma. PMID: 12532041
    20. Keratin 9 is mutated in epidermolytic palmoplantar keratoderma PMID: 14675368
    21. Keratin 9 gene mutation is associated with diffuse palmoplantar keratoderma. PMID: 16043929
    22. A heterozygous nucleotide T-->C transition at position 500 in exon 1 of KRT9 was detected, which resulted in a leucine to serine (L167S) change. PMID: 17362238
    23. A missense mutation in keratin 9 -- Met157Arg in the 1A domain -- was found in a Chinese family with EPPK PMID: 18477167
    24. the first family from Northeast China affected by epidermolytic palmoplantar keratoderma (EPPK) in which we confirmed the presence of the N161S mutation as the result of a 548A>G transition in exon1 of the keratin 9 gene. PMID: 18573708
    25. We show that in a family affected by EPPK and knuckle pad keratosis, carrying the R163W substitution, wild type (wt) and mutated K9 are strongly expressed in knuckle pads. This suggests that the knuckle pad phenotype is due to ectopical expression of K9. PMID: 19106041
    26. The genomic DNA from the patient's peripheral blood showed an R162W mutation in the keratin 9 gene. We therefore diagnosed the patient with Vorner type EPPK. PMID: 19451521
    27. Prenatal diagnosis of epidermolytic palmoplantar keratoderma caused by c.T470C (p.M157T) of the keratin 9 gene. PMID: 19548225

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  • 相關(guān)疾病：
    Keratoderma, palmoplantar, epidermolytic (EPPK)
  • 蛋白家族：
    Intermediate filament family
  • 組織特異性：
    Expressed in the terminally differentiated epidermis of palms and soles.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6447

    OMIM: 144200

    KEGG: hsa:3857

    STRING: 9606.ENSP00000246662

    UniGene: Hs.654569



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