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  4. NCAN Recombinant Monoclonal Antibody

NCAN Recombinant Monoclonal Antibody

  • 中文名稱：
    NCAN Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA197041A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: A2780 whole cell lysate(30μg)
      All lanes: Neurocanantibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 143 kDa
      Observed band size: 143 kDa
      Exposure time：1min
    • IHC image of CSB-RA197041A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    NCAN
  • 別名：
    Neurocan core protein (Chondroitin sulfate proteoglycan 3), NCAN, CSPG3 NEUR
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from Human NCAN protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    18H12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
  • 基因功能參考文獻：
    1. NCAN rs2228603 is not a risk factor for the incidence of NAFLD in Chinese population. The dual and opposite role of T variant in protecting liver with a higher level of HDL was found. PMID: 27887608
    2. This study aims to analyze the influences of single-nucleotide polymorphism in the NCAN-CILP2 region on non-alcoholic fatty liver disease and plasma lipid levels in the Asian and Pacific ethnic groups. PMID: 26758378
    3. NCAN genotype is associated with limbic gray matter alterations in healthy and subjects with major depression in brain areas implicated in emotion perception and regulation PMID: 25801500
    4. current data demonstrate that common genetic variation in NCAN influences both neural processing and cognitive performance in healthy subjects. PMID: 25220293
    5. The frequency of the NCAN rs2228603 T allele was significantly increased in patients with HCC due to ALD (15.1%) compared to alcoholic cirrhosis without HCC (9.3%), alcoholic controls (7.2%), healthy controls (7.9%), and HCV associated HCC (9.1%). PMID: 24946282
    6. NCAN risk variant is associated with cortical folding and thickness in bipolar disorder and schizophrenia. PMID: 23795679
    7. Conditional analysis shows that a neighbouring gene, TM6SF2, not NCAN, is responsible for the Chr 19 GWAS locus previously associated with fibrosing non-alcoholic fatty liver disease (NAFLD). PMID: 24978903
    8. NCAN rs2228603[T] is a risk factor for liver inflammation and fibrosis, suggesting that this locus is responsible for progression from steatosis to steatohepatitis. PMID: 23594525
    9. no genetic association between risk allele A for NCAN locus rs1064395 and schizophrenia. PMID: 23198940
    10. In the combined patient sample, the NCAN risk allele was significantly associated with the "mania" factor, in particular the subdimension "overactivity. PMID: 22952076
    11. The rs1064395 A-allele was significantly over-represented in schizophrenia patients compared to controls. Our data suggest that genetic variation in NCAN is a common risk factor for bipolar disorder and schizophrenia. PMID: 22497794
    12. High neurocan is associated with the invasive phenotype of low-grade astrocytoma. PMID: 21997179
    13. Sex (male)-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels is observed both the Mulao and Han ethnic groups. PMID: 22208664
    14. Genetic variation in the neurocan gene (NCAN) showed genome-wide significant association with bipolar disorder. PMID: 21353194

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Aggrecan/versican proteoglycan family
  • 組織特異性：
    Brain.
  • 數據庫鏈接：

    HGNC: 2465

    OMIM: 600826

    KEGG: hsa:1463

    STRING: 9606.ENSP00000252575

    UniGene: Hs.169047



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