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  4. SIRPB1 Recombinant Monoclonal Antibody

SIRPB1 Recombinant Monoclonal Antibody

  • 中文名稱：
    SIRPB1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA021335MA1HU
  • 規格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human SIRPB1 with Anti-SIRPB1 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA.Immobilized Human SIRPB1(CSB-MP021335HUd7) at 2 μg/mL can bind anti-SIRPB1 recombinant antibody.The EC50 is 0.9675-1.114 ng/mL.
    • The Binding Activity of Human SIRPB1 with Anti-SIRPB1 recombinant antibody
      Activity: SIRPB1 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human SIRPB1(CSB-MP021335HUd7) with an affinity constant of 0.245 nM as detected by MetaSPR Assay (WeSPRTM 200).
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Signal-regulatory protein beta-1 (SIRP-beta-1) (CD172 antigen-like family member B) (CD antigen CD172b), SIRPB1
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human SIRPB1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    14H12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, SPR
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP.
  • 基因功能參考文獻：
    1. SIRPB1 copy-number polymorphism was significantly associated with impulsive-disinhibited personality scores in a dose-dependent manner. PMID: 25039969
    2. SIRPbeta1 is a novel IFN-induced microglial receptor that supports clearance of neural debris and Abeta aggregates by stimulating phagocytosis. PMID: 19893026
    3. SIRP beta 1 is a disulfide-linked homodimer in leukocytes that regulates neutrophil transepithelial migration PMID: 16081415
    4. This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia. PMID: 19034380
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Detected in monocytes and dendritic cells.
  • 數據庫鏈接：

    HGNC: 15928

    OMIM: 603889

    UniGene: Hs.664861



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