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  4. TNNI1 Recombinant Monoclonal Antibody

TNNI1 Recombinant Monoclonal Antibody

  • 中文名稱：
    TNNI1 Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA114453A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA114453A0HU diluted at 1:100 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    TNNI1
  • 別名：
    Troponin I, slow skeletal muscle (Troponin I, slow-twitch isoform), TNNI1
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from Human TNNI1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    22E9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • 基因功能參考文獻(xiàn)：
    1. Ultrasensitive troponin I was detectable in almost all individuals of a study sample reflecting middle-aged to elderly European general population. Ultrasensitive troponin concentrations exhibit an independent, graded, positive relation with incident CHD [coronary heart disease]. PMID: 28585121
    2. Measuring mean platelet volume in conjunction with troponin I levels improves the diagnostic value of troponin I in acute coronary syndrome. PMID: 27524214
    3. CT-1 was found to be associated with Tn-I, which is used to detect myocardial damage after OPCAB surgery. CT-1 may also be used to detect myocardial damage. PMID: 26334851
    4. TNNI3K is a cardiac-specific gene, encoding a cardiac troponin I-interacting MAP kinase. In mice, Tnni3k is shown to play an important role in the regulation of cardiac differentiation and cardiac contractility PMID: 25791106
    5. sTnI as a sensitive marker of skeletal muscle injury. PMID: 22323298
    6. Elevations of troponin I and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are common in patients with atrial fibrillation and independently related to increased risks of stroke and mortality. PMID: 22374183
    7. Elevated post-operative troponin 1 levels predict long-term mortality in older patients undergoing emergency orthpedic surgery. PMID: 19811558
    8. Evaluated the prevalence of TNN13 gene mutations in sudden death caused by cardiomyopathy (CM); in dilated CM cases, a new missense mutation Pro16Thr was detected. A single nucleotide polymorphism at -8 position of intron 3 was identified. PMID: 20817590
    9. troponin I phosphorylation has a role in protein kinase C-mediated enhanced contractile performance of myocytes PMID: 12815045
    10. MEF2 activation of the troponin I slow enhancer is repressed by hMusTRD1alpha1 PMID: 12857748
    11. Low expression of ssTnI was found in 60% of patients in sinus rhythm or paroxysmal AF and in 8% of patients with chronic AF. Relative ssTnI mRNA expression was significantly lower in patients with AF than in those in sinus rhythm. PMID: 15289369
    12. A biological marker of myocardial injury, but may also be increased after a grand mal seizure. PMID: 15367881
    13. These results suggest that this R21C mutation in TnI affects the Ca(2+)-sensitizing effect of Tn, the ability of TnI to be readily phosphorylated by PKA and the stability of TnI to calpain. PMID: 16005017
    14. Relationship between myocardial injury, assessed by cardiac troponin I (cTnI) levels, and outcome in selected critically ill patients without acute coronary syndromes or cardiac dysfunction PMID: 16236952
    15. This marker in paatients with heart failure and anemia identifies patients at particularly high risk mortality. PMID: 16338262
    16. Increased serum levels of troponin I is associated with calcinosis and coronary Artery Stenosis PMID: 16358990
    17. The plasma levels of CRP and troponin I were also significantly higher in this group of nine patients, and correlated with urinary protein excretion. PMID: 16916777
    18. A revised method of troponin exchange in pemeabilized cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I. PMID: 17051347
    19. a localized N-terminal region of TnI comprised of amino acids 33-80, which interacts with C-terminal regions of cTnC and cTnT, is of particular significance in transducing signaling of thin filament activation by strong cross-bridges PMID: 17099250

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  • 蛋白家族：
    Troponin I family
  • 組織特異性：
    Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle cell myoblasts and myotubes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11945

    OMIM: 191042

    KEGG: hsa:7135

    STRING: 9606.ENSP00000337022

    UniGene: Hs.320890



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