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  4. UPK3A Recombinant Monoclonal Antibody

UPK3A Recombinant Monoclonal Antibody

  • 中文名稱：
    UPK3A Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA909840A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Immunofluorescence staining of Hep-G2 cell with CSB-RA909840A0HU at 1:50 ,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Overlay Peak curve showing MCF-7? cells stained with CSB-RA909840A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    UPK3A
  • 別名：
    Uroplakin-3a (UP3a) (Uroplakin III) (UPIII), UPK3A, UPK3
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from Human UPK3A protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    14D2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:20-1:200
    FC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.
  • 基因功能參考文獻：
    1. High expression level of preoperative serum Uroplakin III is associated with biologically aggressive bladder cancer. PMID: 25743828
    2. High Uroplakin III expression is associated with bladder urothelial carcinoma from malignancy metastatic to the urinary bladder. PMID: 25368291
    3. a strong association between UPIII and in the group with tumor recurrence PMID: 24553301
    4. Loss of p63 expression is a prerequisite for uroplakin III expression in urothelial bladder cancer. PMID: 14654529
    5. Our results indicate that de novo mutations in UPIIIA can be involved in defective early kidney development, but probably constitute only a rare cause of human renal hypodysplasia in a minor subset of individuals [UPIIIA]. PMID: 16731295
    6. uroplakin III and III-delta4 genes were significantly up-regulated only in patients with nonulcerative interstitial cystitis PMID: 17698128
    7. Uroplakin III mRNA is up-regulated to a greater extent in vesicoureteral reflux than in control exfoliated urinary cells. PMID: 17880289
    8. Loss of UP III expression is associated with established markers of biologically aggressive bladder cancer PMID: 18313120
    9. Not a useful immunohistochemical marker for detection of pleural malignant mesothelioma. PMID: 18528285
    10. Uroplakin III plays a pivotal role in Eshcerichia coli UTI pathogenesis. PMID: 19007907
    11. studies suggest that bacteria-induced UPIIIa signaling is a critical mediator of bladder responses to insult by uropathogenic E. coli PMID: 19412341

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  • 相關疾病：
    Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Uroplakin-3 family
  • 組織特異性：
    Expressed in ureter.
  • 數據庫鏈接：

    HGNC: 12580

    OMIM: 611559

    KEGG: hsa:7380

    STRING: 9606.ENSP00000216211

    UniGene: Hs.632787



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