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  4. VAV2 Recombinant Monoclonal Antibody

VAV2 Recombinant Monoclonal Antibody

  • 中文名稱：
    VAV2 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA962593A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of VAV2 expression in HepG2 cells using VAV2 antibody. Green, isotype control; red, VAV2.
    • Immunocytochemical staining of HepG2 cells with VAV2 antibody. Nuclei were stained blue with DAPI; VAV2 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
    • Western blotting analysis using VAV2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with VAV2 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    VAV2; Vav Guanine Nucleotide Exchange Factor 2; Guanine Nucleotide Exchange Factor VAV2; Vav 2 Oncogene; VAV-2; Vav 2 Guanine Nucleotide Exchange Factor
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    A synthesized peptide derived from Human VAV2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    17D4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:4000-1:20000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
  • 基因功能參考文獻(xiàn)：
    1. VAV2 polymorphisms associate with cardiovascular risk factors and target organ damage. PMID: 28157227
    2. Study found that Vav2, is overexpressed in human prostate cancer and enhanced AR and AR splicing variant activity. PMID: 28811363
    3. High VAV2 expression is associated with breast cancer. PMID: 26910843
    4. Manipulating steroidogenic factor-1 (SF-1) and nucleotide exchange factor VAV-2 (VAV2) abundance in cultured adrenocortical carcinoma (ACC) cells indicate that VAV2 was a critical factor for SF-1-induced cytoskeletal remodeling and invasion in culture and in vivo (chicken chorioallantoic membrane) models. PMID: 28270555
    5. Data indicate that phosphorylated cortactin recruits Vav2 to activate Rac3 and promote invadopodial maturation in invasive breast cancer cells. PMID: 28356423
    6. autocrine VEGF and IL-8 promoted endothelial cell migration via the Src/Vav2/Rac1/PAK1 signaling pathway. PMID: 28278510
    7. We concluded that Vav2 might promote invasion and metastasis of gastric cancer by regulating some invasion and metastasis-related genes. PMID: 28459214
    8. work suggested that EphB3 acted as a tumor promoter in Papillary Thyroid Cancer by increasing the in vitro migration as well as the in vivo metastasis of Papillary Thyroid Cancer cells through regulating the activities of Vav2 and Rho GTPases in a kinase-dependent manner. PMID: 27986811
    9. The crystal structure of the complex between a phosphorylated PPxY motif of TXNIP and the SH2 domain of Vav2 reveals a conserved recognition mechanism. PMID: 26919541
    10. Our data provide the first evidence to implicate VAV2 in glucose-induced Rac1 activation, actin remodelling and glucose-stimulated insulin secretion in pancreatic beta cells. PMID: 26224100
    11. VAV2 is required for Met signaling in the perinuclear endosome. PMID: 24835487
    12. Authors propose a model whereby vimentin promotes FAK stabilization through VAV2-mediated Rac1 activation. This model may explain why vimentin expressing metastatic lung cancer cells are more motile and invasive. PMID: 24858039
    13. Data suggest a coordination between paxillin kinase linker (PKL)/Vav2 signaling and PKL/beta-PIX signaling during cell migration. PMID: 23615439
    14. the guanine nucleotide exchange factor (GEF) Vav2 is identified as a candidate partner for KCC3. PMID: 23724134
    15. Two variants of VAV2 and VAV3, rs2156323 and rs2801219, respectively, were identified in Japanese patients with primary open angle glaucoma, normal tension glaucoma, and developmental glaucoma. PMID: 23402756
    16. Upregulation of Rac1 activity by Wnt3a temporally correlated with enhanced p120-catenin binding to Rac1 and Vav2. PMID: 22946057
    17. Studies indicate relevance of P-Rex1 and P-Rex2a, in breast tumorigenesis, and suggest that the exchange factors Vav2 and Vav3 play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and metastasis. PMID: 23033535
    18. Data indicate that Vav2 and Vav3 controlled a vast transcriptional program in breast cancer cells through mechanisms that were shared between the two proteins, isoform-specific or synergistic. PMID: 23033540
    19. The structural basis for the interaction between Arap3 and Vav2, hydrophobic pockets and binding specificity. PMID: 22750419
    20. VAV2 specifically interacts with activated Galpha(q) but not with Galpha(s) subunits, competing with parathyroid hormone receptor for coupling to Galpha(q). PMID: 22554804
    21. Type IV pili producing Neisseria gonorrhoeae triggers a phosphotyrosine-dependent Cav1-Vav2-RhoA signaling cascade that elicits cytoskeletal rearrangements and effectively impedes bacterial uptake into host cells. PMID: 20808760
    22. VAV2 has been identified as a candidate gene in a genome-wide association study of German multiple sclerosis patients. PMID: 20598377
    23. present data indicate a lack of involvement of variations in NTF4, VAV2, and VAV3 with glaucoma pathogenesis in an Indian population. PMID: 20463313
    24. Data strongly suggest that VAV2 and VAV3 genes are susceptibility loci in Japanese primary open-angle glaucoma. PMID: 20140222
    25. Together, we suggest that balanced Vav2 activity is necessary for optimal neurite outgrowth and promotes branching by targeting GEF activity to branch points. PMID: 20298788
    26. Vav2 can regulate growth factors receptor signalling by slowing receptor internalization and degradation through its interaction with endosome-associated proteins. PMID: 20140013
    27. Interaction of L2 with Vav2 was mediated by the N-terminus of L2 and independent of the N-terminus of Vav2. PMID: 19451809
    28. RhoA knockdown intensified the Vav2-induced disruption of acini, leading to more aggressive cell outgrowth and branching morphogenesis. PMID: 19826000
    29. Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation. PMID: 11909943
    30. Vav2 and Tiam1 may act as downstream effectors of Src, thereby regulating Rac1-dependent pathways that participate in Src-induced cell transformation PMID: 12810717
    31. Rap1 promotes cell spreading by localizing a subset of Rac GEFs to sites of active lamellipodia extension PMID: 15479739
    32. Vav2-mediated nucleotide exchange of Rho GTPases follows the Theorell-Chance catalytic mechanism in which Vav2.Rho GTPase complex is the major species during the exchange process and Vav2.GDP-Mg2+.Rho GTPase ternary complex is present only transiently. PMID: 15850391
    33. The EGFR/Vav2/Rac1 axis is a crucial pathway for the acquisition of motile and invasive properties of most head and neck squamous cell carcinoma cells. PMID: 17234718
    34. Vav2 acts downstream of VEGF to activate Rac1. PMID: 17686471
    35. IMC-C225 cross-links integrins with EGFR, leading to Vav2-dependent activation of RhoA PMID: 18829495
    36. Vav2 is a GDP/GTP exchange factor (GEF) for Rac in vivo. PMID: 11448999

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  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12658

    OMIM: 600428

    KEGG: hsa:7410

    STRING: 9606.ENSP00000360916

    UniGene: Hs.369921



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