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  4. Recombinant Danio rerio DNA damage-binding protein 2 (ddb2)

Recombinant Danio rerio DNA damage-binding protein 2 (ddb2)

  • 中文名稱：
    Recombinant Danio rerio DNA damage-binding protein 2(ddb2)
  • 貨號：
    CSB-YP652125DIL
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Danio rerio DNA damage-binding protein 2(ddb2)
  • 貨號：
    CSB-EP652125DIL
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Danio rerio DNA damage-binding protein 2(ddb2)
  • 貨號：
    CSB-EP652125DIL-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Danio rerio DNA damage-binding protein 2(ddb2)
  • 貨號：
    CSB-BP652125DIL
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Danio rerio DNA damage-binding protein 2(ddb2)
  • 貨號：
    CSB-MP652125DIL
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ddb2; si:dkey-45f10.3DNA damage-binding protein 2; Damage-specific DNA-binding protein 2
  • 種屬：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-496
  • 氨基酸序列
    MARGRAQTDS AASKQTKTVN SKKRPNEETP QPSTKKLKAK QQHKSKQKEE TYIQASVKWT GGQKKVGQTS ILHYIYKSSL GQSIHAQLRQ CLQEPFIRSL KSYKLHRTAS PFDRRVTSLE WHPTHPTTVA VGSKGGDIIL WDYDVLNKTS FIQGMGPGDA ITGMKFNQFN TNQLFVSSIW GATTLRDFSG SVIQVFAKTD SWDYWYCCVD VSVSRQMLAT GDSTGRLLLL GLDGHEIFKE KLHKAKVTHA EFNPRCDWLM ATSSVDATVK LWDLRNIKDK NSYIAEMPHE KPVNAAYFNP TDSTKLLTTD QRNEIRVYSS YDWSKPDQII IHPHRQFQHL TPIKATWHPM YDLIVAGRYP DDQLLLNDKR TIDIYDANSG GLVHQLRDPN AAGIISLNKF SPTGDVLASG MGFNILIWNR EDTLSSVNRK QTIVTGEDVG GRAGGSRSQR SSQQRPSRDR RAAADEAKLK KKLSATETKS KTKSKTESKT SKSKKK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair.
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    WD repeat DDB2/WDR76 family
  • 數據庫鏈接：

    UniGene: Dr.94422



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