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  4. Recombinant Human Betaine--homocysteine S-methyltransferase 1 (BHMT)

Recombinant Human Betaine--homocysteine S-methyltransferase 1 (BHMT)

  • 中文名稱：
    Recombinant Human Betaine--homocysteine S-methyltransferase 1(BHMT)
  • 貨號：
    CSB-YP835892HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Betaine--homocysteine S-methyltransferase 1(BHMT)
  • 貨號：
    CSB-EP835892HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Betaine--homocysteine S-methyltransferase 1(BHMT)
  • 貨號：
    CSB-EP835892HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Betaine--homocysteine S-methyltransferase 1(BHMT)
  • 貨號：
    CSB-BP835892HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Betaine--homocysteine S-methyltransferase 1(BHMT)
  • 貨號：
    CSB-MP835892HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    BHMT
  • Uniprot No.：
  • 別名：
    Betaine homocysteine methyltransferase; Betaine homocysteine S methyltransferase 1; Betaine homocysteine S methyltransferase; Betaine--homocysteine S-methyltransferase 1; BHMT; BHMT1; BHMT1_HUMAN; EC 2.1.1.5; Epididymis secretory sperm binding protein Li 61p; HEL S 61p
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    2-406
  • 氨基酸序列
    PPVGGKKAK KGILERLNAG EIVIGDGGFV FALEKRGYVK AGPWTPEAAV EHPEAVRQLH REFLRAGSNV MQTFTFYASE DKLENRGNYV LEKISGQEVN EAACDIARQV ADEGDALVAG GVSQTPSYLS CKSETEVKKV FLQQLEVFMK KNVDFLIAEY FEHVEEAVWA VETLIASGKP VAATMCIGPE GDLHGVPPGE CAVRLVKAGA SIIGVNCHFD PTISLKTVKL MKEGLEAARL KAHLMSQPLA YHTPDCNKQG FIDLPEFPFG LEPRVATRWD IQKYAREAYN LGVRYIGGCC GFEPYHIRAI AEELAPERGF LPPASEKHGS WGSGLDMHTK PWVRARARKE YWENLRIASG RPYNPSMSKP DGWGVTKGTA ELMQQKEATT EQQLKELFEK QKFKSQ
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
  • 基因功能參考文獻：
    1. Our study suggested markers in BHMT/BHMT2 and DMGDH might affect the risk of NSCL/P through pairwise interaction. PMID: 29356306
    2. BHMT (rs3733890) polymorphism showed no association with ALL. Hence this investigation needs further evaluation in larger sample size and effect of other SNPs, CNVs and miRNA's is required to elucidate the role of BHMT gene in ALL development. PMID: 28582843
    3. In genotypic combination analysis considering PEMT -744GG/CHDH +432GG/BHMT +742GG as the reference combination, PEMT -744GC/CHDH +432GG/BHMT +742GG genotypic combination was significantly higher in mothers of a down syndrome child compared with that in control mothers with an odds ratio of 2.061 (95% CI: 1.10-3.86, P=0.0342). PMID: 27677362
    4. It was concluded that during pregnancy, the BHMT pathway is affected by folate status and by the variant BHMT c.716A allele. PMID: 27735840
    5. low BHMT expression is correlated with aggressive malignant phenotype of HCC. Our data indicate that BHMT may serve as a novel prognostic marker for HCC. PMID: 26592251
    6. The faster evolutionary rate of BHMT2 overall suggests that selective constraints were reduced relative to BHMT. PMID: 26213999
    7. Multiple SNPs in BHMT and BHMT2 were identified to be associated with the occurrence of infant obstructive heart defects and interaction effects with maternal use of folic acid supplements. PMID: 25846410
    8. Data suggest BHMT is activated by binding of potassium ions; role of potassium ions in BHMT appears to be structural; potassium ions facilitate specific binding of substrate homocysteine (rather than substrate betaine) to active site of the enzyme. PMID: 24895213
    9. Study suggests BHMT holds considerable potential as a blood biomarker for acute liver injury. PMID: 25144858
    10. Women harboring the single nucleotide polymorphism BHMT 742G>A have a decreased risk of a Down Syndrome pregnancy. PMID: 23645037
    11. Known common single-nucleotide polymorphisms in MTRR and BHMT genes may not be significant risk factors for cororonary artery disease. PMID: 22339686
    12. Our study suggests that the polymorphism BHMT G742A may modulate the Down syndrome risk in Brazilian mothers. PMID: 22339736
    13. The BHMT 742GA or AA genotypes associated with tobacco consumption (P = 0.016) increase the risk for head and neck squamous cell carcinoma. PMID: 21630102
    14. A transcription variant of exon 4 of betaine-homocysteine methyltransferase (BHMT) produces a loss of function of BHMT in human hepatocarcinoma PMID: 22138536
    15. Three SNPs (rs41272270, rs16876512, and rs6875201), located 28kb upstream, in the 5'-UTR and in intron 1 of BHMT, respectively, were significantly correlated with both BHMT activity and protein levels. PMID: 21093336
    16. No significant level of association was found with cleft lip with or without cleft palate and BHMT variants. PMID: 21564312
    17. Results might suggest the protective role of the BHMT 239Gln variant in cervical cancer incidence. PMID: 21349258
    18. This suggests that polymorphism rs3797546 in the BHMT gene may confer genetic risk of NSCL/P in a recessive manner. PMID: 21565678
    19. gene-gene interaction analysis revealed significant epistatic interaction of BHMT2 (rs673752), PEMT (rs12325817), and PCYT1A (rs712012) with maternal NCL/P susceptibility. PMID: 20662904
    20. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) PMID: 19948975
    21. mutagenesis of the zinc-binding motif reveals that Gly 214 is essential PMID: 11883905
    22. BHMT is a tetramer and its ability to methylate homocysteine is not affected by S-Adenosylmethionine (SAMe) PMID: 12071701
    23. X-ray structures of human BHMT in its oxidized (Zn-free) and reduced (Zn-replete) forms, the latter in complex with the bisubstrate analog, S(delta-carboxybutyl)-L-homocysteine, were determined at resolutions of 2.15 A and 2.05 A PMID: 12220488
    24. Study using intrinsic tryptophan fluorescence properties of BHMT demonstrates clearly that BHMT catalysis follows an ordered bi-bi mechanism and that betaine binding affinity is dependent on formation of the BHMT-homocysteine complex. PMID: 15122900
    25. S-adenosylmethionine and methylthioadenosine downregulaate BHMT expression in HepG2 cells. PMID: 16953798
    26. association between the homozygous mutant form of BHMT (742G-->A) polymorphism and increased risk for placental abruption. PMID: 17376725
    27. The BHMT/betaine system directly protects hepatocytes from homocysteine-induced injury but not tunicamycin-induced injury, including an endoplasmic reticulum stress response, lipid accumulation, and cell death. PMID: 17705221
    28. Experiments using the glutamate-cysteine ligase modifier subunit knockout mice Gclm(-/-), which are severely impaired in glutathione synthesis, show that BHMT activity is reduced about 75% in Gclm(-/-) compared to Gclm(+/+) mice. PMID: 18262489
    29. Common genetic variation in BHMT and BHMT2 and functionally characterized BHMT SNPs. PMID: 18457970
    30. betaine-homocysteine methyltransferase (BHMT) transgenic mice are resistant to alcohol or high methionine low folate diet -induced hyperhomocysteinemia and liver steatosis PMID: 18498552
    31. The BHMT 742 A allele was associated with resuced all-cause mortality. PMID: 18708404
    32. betaine-homocysteine methyltransferase gene (BHMT) rs3733890 polymorphism was associated with reduced breast cancer-specific mortality (hazard ratio, 0.64; 95% confidence interval, 0.42-0.97) PMID: 19635752

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  • 亞細胞定位：
    Cytoplasm.
  • 組織特異性：
    Found exclusively in liver and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1047

    OMIM: 602888

    KEGG: hsa:635

    STRING: 9606.ENSP00000274353

    UniGene: Hs.80756



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