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  4. Recombinant Human ETS translocation variant 5 (ETV5), partial

Recombinant Human ETS translocation variant 5 (ETV5), partial

  • 中文名稱：
    Recombinant Human ETS translocation variant 5 (ETV5), partial
  • 品名簡稱：
    Recombinant Human ETV5 protein, partial
  • 貨號：
    CSB-EP007859HU
  • 說明書：
  • 規格：
    ￥1536
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    ETV5
  • Uniprot No.：
  • 別名：
    Ets-related protein ERM
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    22.3 kDa
  • 表達區域：
    124-265aa
  • 氨基酸序列
    DRKPPSGFKPLTPPTTPLSPTHQNPLFPPPQATLPTSGHAPAAGPVQGVGPAPAPHSLPEPGPQQQTFAVPRPPHQPLQMPKMMPENQYPSEQRFQRQLSEPCHPFPPQPGVPGDNRPSYHRQMSEPIVPAAPPPPQGFKQE
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    C-terminal 6xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.
  • 基因功能參考文獻：
    1. exploration of the underlying mechanism demonstrated that ICAM3 not only binds to LFA-1 with its extracellular domain and structure protein ERM but also to lamellipodia with its intracellular domain which causes a tension that pulls cells apart (metastasis). PMID: 29729315
    2. High Etv5 expression is associated with glioma. PMID: 29787563
    3. Novel ETV5 SNP rs7647305 is associated with childhood hypertension adjusted by obesity. PMID: 28645872
    4. MiR-200b inhibition by transfection in MCF-7 markedly decreased miR-200b level, elevated ERM expression, and enhanced cell migration and invasion. MiR-200b overexpression in MDA-MB-231 obviously increased miR-200b level, reduced ERM expression, and weakened cell migration and invasion. PMID: 27276064
    5. Resistin, a fat-derived secretory factor, promotes metastasis of MDA-MB-231 human breast cancer cells through ERM activation PMID: 26729407
    6. ERM proteins contribute toward accelerated CD44 shedding by MT1-MMP through ERM protein-mediated interactions between their cytoplasmic tails. PMID: 26289026
    7. Our results reveal a novel ERM-based spatial mechanism that is coopted by DLBCL cells to sustain tumor cell growth and survival. PMID: 25801911
    8. Increase of ETV5 protein expression is associated with endometrial cancer invasion. PMID: 25924802
    9. Snail regulates the motility and invasiveness of oral cancer cells via RhoA/Cdc42/p-ERM pathway. PMID: 25172658
    10. there is a higher expression of ERM/ETV5 in early stages of endometrioid endometrial carcinomas PMID: 24756106
    11. we found that the downregulation of ETV5 reduced the expression of the oncogenic transcription factor FOXM1. PMID: 22589409
    12. This data suggests that ETV5 has a significant role in regulating MMP2 expression and therefore matrix resorption in human chondrosarcoma, and thus may be a targetable upstream effector of the metastatic cascade in this cancer. PMID: 22968857
    13. we propose ETV5-transcriptional regulation of the EMT process through a crosstalk with the tumor surrounding microenvironment, as a principal event initiating EC invasion. PMID: 22266854
    14. The homozygous +48845 G>T (TT allele) variant confers a higher risk for male infertility associated with nonobstructive azoospermia and Sertoli cell only syndrome in Australian men. PMID: 22771031
    15. Upregulation of ETV5 induced the expression of cell adhesion molecules and enhanced cell survival in a spheroid model. PMID: 21520040
    16. results indicate concurrent mechanisms in expression of MMP-2 and -9, RUNX1/AML1 and ETV5/ERM, and several basement membrane components, which likely associate with the invasive stage of endometrioid endometrial and ovarian endometrioid carcinoma. PMID: 20970160
    17. The flexible nature of transactivation domain may be instrumental for ERM recognition and binding to diverse molecular partners. PMID: 20647002
    18. functional role for the ERMs (ezrin/radixin/moesin) as adaptor molecules in the interactions of adhesion receptors and intracellular tyrosine kinases PMID: 12387735
    19. ERM has a role in progression of breast cancer PMID: 15534105
    20. The erm gene expression is regulated by the conventional PKC (cPKC) pathway. PMID: 15620692
    21. CD44-mediated hyaluronan binding in myeloid cells is regulated by phosphorylated ERM and the actin cytoskeleton. PMID: 15652352
    22. ERM is subject to SUMO modification and this post-translational modification causes inhibition of transcription-enhancing activity PMID: 15857832
    23. Erm is involved in SP-C regulation, which results from an interaction with TTF-1 PMID: 16613858
    24. analysis of NHERF recognition by ERM proteins PMID: 16615918
    25. Testing various shorter fragments of ERM as bait indicated that the region essential for binding CHD3/ZFH is within the amino acid region 96-349, which contains the central inhibitory DNA-binding domain (CIDD) of ERM PMID: 17489097
    26. ERM/ETV5 up-regulation activates MMP-2 and thus has a role during myometrial infiltration in endometrial cancer PMID: 17638886
    27. A TMPRSS2:ETV5 gene fusion was identified in prostate cancer. PMID: 18172298

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 3494

    OMIM: 601600

    KEGG: hsa:2119

    STRING: 9606.ENSP00000306894

    UniGene: Hs.43697



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