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  4. Recombinant Human Electrogenic sodium bicarbonate cotransporter 4 (SLC4A5), partial

Recombinant Human Electrogenic sodium bicarbonate cotransporter 4 (SLC4A5), partial

  • 中文名稱：
    人SLC4A5重組蛋白
  • 貨號：
    CSB-YP874837HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLC4A5重組蛋白
  • 貨號：
    CSB-EP874837HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLC4A5重組蛋白
  • 貨號：
    CSB-EP874837HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLC4A5重組蛋白
  • 貨號：
    CSB-BP874837HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLC4A5重組蛋白
  • 貨號：
    CSB-MP874837HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC4A5
  • Uniprot No.：
  • 別名：
    Electrogenic sodium bicarbonate cotransporter 4; MGC129662; NBC4; NBCe2; S4A5_HUMAN; SLC4A5; Solute carrier family 4 member 5; Solute carrier family 4 sodium bicarbonate cotransporter member 5
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.
  • 基因功能參考文獻：
    1. NBCe2 activity is stimulated by an increase in intracellular sodium and is hyper-responsive in hRPTCs carrying HV SLC4A5 rs7571842 through an aberrant HNF4A-mediated mechanism PMID: 29642240
    2. NBCe2 could be important in proximal kidney tubule apical sodium and bicarbonate cotransport under high-salt conditions. PMID: 26447209
    3. we summarize the potential function of NBCe2 in the regulation of blood pressure, acid-base, and K(+) and Ca(2+) transport in the distal nephron--{REVIEW} PMID: 26136555
    4. Data indicate that 2 SNPs in SLC4A5 (rs7571842 and rs10177833) showed highly significant results and large effects sizes. PMID: 22987918
    5. The additive effect of rs10177833 of SLC4A5 on systolic blood pressure is statistically different between women with dark skin color and women with medium skin color (P = .0153). PMID: 22764636
    6. Summarizing, the observed associations with resting and submaximal-exercise cardiovascular and metabolic traits in the HERITAGE Family Study are likely due to neither variation in the promoter nor known coding SNPs of SLC4A5 PMID: 19384345
    7. Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued). PMID: 12063394
    8. These results additionally confirm the involvement of SLC4A5 with blood pressure control, although the mechanism is still unclear. PMID: 16365189

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  • 亞細胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Anion exchanger (TC 2.A.31) family
  • 組織特異性：
    Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach a
  • 數據庫鏈接：

    HGNC: 18168

    OMIM: 606757

    KEGG: hsa:57835

    STRING: 9606.ENSP00000350475

    UniGene: Hs.594099



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