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  4. Recombinant Human Electron transfer flavoprotein subunit beta(ETFB)

Recombinant Human Electron transfer flavoprotein subunit beta(ETFB)

  • 中文名稱：
    Recombinant Human Electron transfer flavoprotein subunit beta(ETFB)
  • 品名簡稱：
    Recombinant Human ETFB protein
  • 貨號：
    CSB-EP007845HU
  • 說明書：
  • 規格：
    ￥1536
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    ETFB
  • Uniprot No.：
  • 別名：
    Beta-ETF;ETFB;FP585
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    34.6 kDa
  • 表達區域：
    2-255aa
  • 氨基酸序列
    AELRVLVAVKRVIDYAVKIRVKPDRTGVVTDGVKHSMNPFCEIAVEEAVRLKEKKLVKEVIAVSCGPAQCQETIRTALAMGADRGIHVEVPPAEAERLGPLQVARVLAKLAEKEKVDLVLLGKQAIDDDCNQTGQMTAGFLDWPQGTFASQVTLEGDKLKVEREIDGGLETLRLKLPAVVTADLRLNEPRYATLPNIMKAKKKKIEVIKPGDLGVDLTSKLSVISVEDPPQRTAGVKVETTEDLVAKLKEIGRI
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    C-terminal 6xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.
  • 基因功能參考文獻：
    1. We identified and replicated a novel gene, ETFB, strongly associated with chronic anthracycline-induced cardiotoxicity independently of age at tumor onset and related to anthracycline-mediated mitochondrial dysfunction PMID: 28913729
    2. These results suggested that increasing levels of ATP5B and ETFB were associated with worsening renal injury. PMID: 27840937
    3. the findings of our present study suggest that ETFbeta plays an important role in renal tubular cell apoptosis during the progression of DN. PMID: 27035869
    4. Electron Transfer Flavoprotein Subunit Beta Is a Candidate Endothelial Cell Autoantigen in Behcet's Disease PMID: 25915519
    5. Human METTL20 is a mitochondrial lysine methyltransferase that targets ETFbeta and modulates its activity. PMID: 25416781
    6. ETFB knockdown can affect TGF-beta-induced tissue remodeling and/or fibrotic processes in vitro. PMID: 23068445
    7. Point mutations in electron-transfer-flavoprotein beta is associated with destabilized conformations and defective protein:protein interactions leading to mitochondrial dysfunction. PMID: 22588007
    8. ETFB participates in the mechanoregulation of fibroblast cell number in collagen gel culture. PMID: 21903359
    9. non-productive conformation stabilization underpins rapid electron transfer to electron-transferring flavoprotein PMID: 15975918
    10. Tissue samples from 16 unrelated patients with ETF deficiency were analysed, two of them harboured mutations in the ETFB gene. PMID: 16510302
    11. conformational and stability properties of the disease-causing variant ETFbeta-D128N, and our findings on the effect of flavinylation in modulating protein conformational stability and activity. PMID: 19088074

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  • 相關疾病：
    Glutaric aciduria 2B (GA2B)
  • 亞細胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    ETF beta-subunit/FixA family
  • 組織特異性：
    Abundant in liver, heart and skeletal muscle. A weak expression is seen in the brain, placenta, lung, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 3482

    OMIM: 130410

    KEGG: hsa:2109

    STRING: 9606.ENSP00000346173

    UniGene: Hs.348531



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