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  4. CD96 (Nelistotug Biosimilar) Recombinant Monoclonal Antibody

CD96 (Nelistotug Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA004971MB2HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    CD96 (Nelistotug Biosimilar Antibody)重組單克隆抗體是一種用于科研領域的生物試劑，主要針對CD96靶點設計開發。CD96作為一種免疫球蛋白超家族成員，在自然殺傷（NK）細胞、T細胞等免疫細胞表面表達，參與免疫調節過程中的細胞間相互作用及信號轉導，其功能機制與腫瘤免疫、自身免疫性疾病等研究密切相關。 該重組單克隆抗體通過基因工程技術制備，具有高特異性和親和力，能夠特異性識別并結合CD96分子，為研究CD96的生理及病理作用提供重要工具。在科研應用中，可用于某些實驗，助力解析CD96在免疫細胞活化、腫瘤微環境調控、免疫逃逸機制等方面的作用。 通過使用CD96重組單克隆抗體，研究人員能夠深入探索CD96與配體（如CD155）的相互作用，揭示其在免疫突觸形成、細胞毒性效應調節中的分子機制，為免疫相關疾病的研究提供實驗基礎。該試劑的應用范圍覆蓋基礎免疫學、腫瘤生物學、細胞生物學等多個領域，為相關領域的科學研究提供可靠的實驗支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    GSK-6097608 research-grade biosimilar ;CD96 antibody; T-cell surface protein tactile antibody; Cell surface antigen CD96 antibody; T cell-activated increased late expression protein antibody; CD antigen CD96 antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CD96 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS,pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
  • 基因功能參考文獻：
    1. Lower CD96 expression was also observed in human IL-9(+) compared with IFN-gamma(+) T cells PMID: 29531070
    2. Blocking CD96 or TIGIT with mAbs has been shown to improve tumor control in mice. PMID: 27620276
    3. CD96 and CD123 are expressed in bone marrow cells of patients with myelodysplastic syndromes PMID: 26642704
    4. In the present study we analyzed the expression of four cell surface antigens relevant to human hematopoiesis-CD90, CD96, CD117, and CD123-in bone marrow from pediatric acute myeloid leukemia patients and normal control subjects. PMID: 24751333
    5. down-regulation of CD96 is an important aspect of HIV-1 pathogenesis and differential expression is related to cell effector functions and HIV-1 disease course. PMID: 23272144
    6. CD96 could serve as a target structure for effector cell-mediated lysis. PMID: 22879978
    7. The positive expression of CD96 on bone marrow hematopoietic stem cells in patients with acute leukemia may be associated with primary drug resistance, relapse and progression. PMID: 21729528
    8. CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR), stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. PMID: 15034010
    9. CD96 is a cell surface marker present on many acute myeloid leukemia leukemic stem cells PMID: 17576927
    10. CD96-driven adhesion to CD155 may be crucial in developmental processes PMID: 19056733

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  • 相關疾?。?/div>
    C syndrome (CSYN)
  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
  • 數據庫鏈接：

    HGNC: 16892

    OMIM: 211750

    KEGG: hsa:10225

    STRING: 9606.ENSP00000283285

    UniGene: Hs.142023



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