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DPEP3 (US10189910B2 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號:
    CSB-RA007125MB1HU
  • 規格:
    ¥83486
  • 其他:

產品詳情

  • 產品描述:
    DPEP3 (US10189910B2 Biosimilar Antibody) 重組單克隆抗體是一種針對人二肽酶3(Dipeptidase 3, DPEP3)重組單克隆抗體,其別名為Dipeptidase 3 antibody、DPEP3 antibody或UNQ834/PRO1772 antibody。該抗體以重組人DPEP3蛋白制備而成,具有高度特異性和親和力,可特異性識別人及食蟹猴(Macaca fascicularis)的DPEP3蛋白,為跨物種研究提供了可靠工具。 DPEP3可基于其參與肽類代謝的膜結合酶特性,開發用于相關疾病的治療。DPEP3的異常表達與多種疾病的發生發展密切相關,如腫瘤微環境調控、炎癥反應及腎臟疾病等,針對這些疾病開發類似物有望通過調控DPEP3活性發揮治療作用。此類藥物與現有治療手段相比,可能具有相似的結構和生物活性,有助于降低治療成本,為患者提供更多治療選擇。目前,針對DPEP3在腫瘤侵襲轉移中的作用及靶向藥物的臨床前研究正在逐步開展,旨在探索其在實體瘤治療中的應用前景。 該抗體可廣泛應用于實驗,助力研究者在分子和細胞水平解析DPEP3的表達模式、亞細胞定位及相互作用蛋白。鑒于其對人和食蟹猴的種屬反應性,該抗體適用于臨床前動物模型與人體樣本的對比研究,為從基礎研究到臨床轉化提供重要支持。此外,通過特異性阻斷DPEP3活性,該抗體可用于探究其在生理病理過程中的功能,為揭示相關疾病的分子機制提供關鍵實驗工具。
  • Uniprot No.:
  • 基因名:
  • 別名:
    Dipeptidase 3 antibody; DPEP3 antibody; UNQ834/PRO1772 antibody
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human DPEP3 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.01M PBS,pH7.4
  • 產品提供形式:
    Liquid
  • 應用說明:
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    In stock
  • 用途:
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能:
    Dipeptidase that hydrolyzes cystinyl-bis-glycine. Does not hydrolyze leukotriene D4 (LTD4) into leukotriene E4 (LTE4).
  • 基因功能參考文獻:
    1. This paper describes differences in substrate specificity and tissue distribution of membrane-bound dipeptidase 3 from mouse in comparison to other mouse members of this family. PMID: 12738806
  • 亞細胞定位:
    Membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族:
    Metallo-dependent hydrolases superfamily, Peptidase M19 family
  • 數據庫鏈接:

    HGNC: 23029

    OMIM: 609926

    KEGG: hsa:64180

    STRING: 9606.ENSP00000268793

    UniGene: Hs.302028



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