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LILRB4 (NGM-831 Biosimilar) Recombinant Monoclonal Antibody

Sequence Pending
  • 貨號:
    CSB-RA850914MB4HU
  • 規格:
    ¥83486
  • 其他:

產品詳情

  • 產品描述:
    LILRB4(NGM-831 Biosimilar Antibody)重組單克隆抗體是一種針對白細胞免疫球蛋白樣受體B4(LILRB4)的科研用生物試劑。該抗體通過基因工程技術重組表達,具有高特異性和親和力,可特異性識別并結合LILRB4蛋白,為相關基礎研究和機制探索提供重要工具。 LILRB4作為免疫球蛋白超家族成員,在免疫調節、炎癥反應及腫瘤微環境調控中發揮關鍵作用。研究表明,LILRB4在單核細胞、巨噬細胞等免疫細胞表面表達,通過與配體相互作用參與免疫抑制信號傳導,其異常表達與多種疾病的發生發展密切相關。因此,該抗體可廣泛應用于LILRB4分子的表達檢測、細胞功能分析及信號通路研究等科研場景。 該重組單克隆抗體采用哺乳動物細胞表達系統制備,經過嚴格的純化和質量控制,確保產品具有高純度和批次穩定性。其應用形式靈活,可用于等多種實驗技術,助力科研人員深入探究LILRB4在免疫調節網絡中的作用機制,為相關疾病的病理生理研究提供有力支持。 作為科研用試劑,該抗體僅用于實驗室研究,不用于臨床診斷或治療。通過特異性靶向LILRB4,為揭示免疫調控分子機制、開發新型治療策略等研究方向提供可靠的實驗材料,推動免疫學及相關領域的基礎研究進展。
  • Uniprot No.:
  • 基因名:
  • 別名:
    NGM 831 research-grade biosimilar; NGM-831 research-grade biosimilar ;LILRB4 antibody; ILT3 antibody; LIR5 antibody; Leukocyte immunoglobulin-like receptor subfamily B member 4 antibody; B4 antibody; CD85 antigen-like family member K antibody; Immunoglobulin-like transcript 3 antibody; ILT-3 antibody; Leukocyte immunoglobulin-like receptor 5 antibody; LIR-5 antibody; Monocyte inhibitory receptor HM18 antibody; CD antigen CD85k antibody
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human LILRB4 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.01M PBS,pH7.4
  • 產品提供形式:
    Liquid
  • 應用說明:
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    3-4 weeks
  • 用途:
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能:
    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
  • 基因功能參考文獻:
    1. Results suggest that ILT3 played an important role in tumor progression in colorectal cancer by possible influence on CD45RO+ T cells in the tumor microenvironment. PMID: 30126665
    2. These results suggest that tyrosine phosphorylation may be critical in FcgammaRI-dependent endocytosis/phagocytosis that may be regulated by LILRB4 by triggering dephosphorylation of key signalling proteins. PMID: 27725776
    3. ILT3 may functionally contribute to a regulatory network controlling tumor progression by suppressing the Akt pathway. PMID: 28931525
    4. The ILT3 PBs/PCs were suggested to be developmentally equivalent based on the simultaneous generation of these populations upon activation of memory B cells in vitro ILT3 expression was found to be induced efficiently by IL-2, while IFN-alpha effectively induced ILT3 PBs/PCs in vitro Utilizing the elevated ILT3 will support opening a new avenue for molecular markers for, pathogenic cells. PMID: 27742834
    5. this study shows that LILRB4 might have dual inhibitory and activating functions, depending on the position of the functional tyrosine residues in its immunoreceptor tyrosine-based inhibitory motifs and/or the nature of the stimuli PMID: 28409541
    6. LILRB4 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    7. Identification of ILT4 as a cellular receptor for CSP C4d PMID: 26678451
    8. ILT3Fc inhibits T cell activation and induces the generation of suppressor T cells targeting multiple inflammatory miRNA pathways. PMID: 22387553
    9. Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance. PMID: 21454581
    10. Data show that LILRB4 is a potent inhibitor of monocyte activation via FcgammaRI. PMID: 19833736
    11. ILT3 precursor RNA is expressed and retained in nuclei of resting endothelial cells. PMID: 16433759
    12. Our findings indicate that expression of ILT3 and ILT4 on CLL B cells represents a phenotypic abnormality that may play a role in tolerization of tumor-specific T cells. PMID: 17266150
    13. The inhibitory effect of serum and membrane ILT3 in a humanized SCID mouse model describes an immune-escape mechanism that could contribute to impaired T cell responses in patients with cancer. PMID: 17513794
    14. Both membrane and soluble ILT3 are proteins with potent immunosuppressive activity which are of importance for treatment of rejection, autoimmunity and cancer. PMID: 17923119
    15. describe an immune-escape mechanism mediated by the inhibitory receptor immunoglobulin-like transcript 3 (ILT3) which may be responsible for failure of pancreatic cancer therapy PMID: 17993722
    16. Progenitor mast cells expressed cell surface inhibitory LILRB4. Mature cord-blood-derived mast cells had detectable mRNA encoding multiple LILRs, none were expressed on the cell surface. PMID: 17998301
    17. ILT3-Fc is a potent immunoregulatory agent that suppresses islet allograft rejection in humanized NOD/SCID mice. PMID: 18420485
    18. 15 single nucleotide polymorphisms are identified in the extracellular domain of immunoglobulin-like transcript 3 gene from healthy individuals. PMID: 18486764
    19. Expressed on cultured osteoclast precursor cells derived from peripheral blood monocytes; could be inhibitory for osteoclast development in presence of receptor activator of NF-kappaB ligand (RANKL) and macrophage colony stimulating factor (M-CSF). PMID: 18802077
    20. A significant association is observed between ILT3 dendritic cells in kidney transplants and donor age. PMID: 19010139
    21. ILT3 may play a critical role in the control of inflammation. PMID: 19380766
    22. A tryptophan-deprived environment generates monocyte-derived dendritic cells with a marked up-regulation of inhibitory receptors ILT3 and ILT4 and enhanced capacity to induce CD4+CD25+Foxp3+ regulatory T cells in an ILT3-dependent manner. PMID: 19535644

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  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment.
  • 組織特異性:
    Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.
  • 數據庫鏈接:

    HGNC: 6608

    OMIM: 604821

    KEGG: hsa:11006

    STRING: 9606.ENSP00000270452

    UniGene: Hs.67846



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