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  4. LRRC32 (Livmoniplimab Biosimilar) Recombinant Monoclonal Antibody

LRRC32 (Livmoniplimab Biosimilar) Recombinant Monoclonal Antibody

  • 中文名稱：
    LRRC32 (Livmoniplimab Biosimilar) Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA618886MB3HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    D11S833E antibody; GARP antibody; Garpin antibody; Glycoprotein A repetitions predominant antibody; Leucine rich repeat containing 32 antibody; Leucine-rich repeat-containing protein 32 antibody; LRC32_HUMAN antibody; LRRC32 antibody; Livmoniplimab
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human LRRC32 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Human IgG4(S228P) kappa
  • 純化方式：
    Affinity-chromatography
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, FACS
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).
  • 基因功能參考文獻：
    1. GARP is a surface molecule of regulatory T cells with roles in the regulatory function and TGF-beta releasing [review] PMID: 27095576
    2. Data show that the Treg activation marker GARP (glycoprotein A repetitions predominant) is expressed on primary melanoma. PMID: 27248166
    3. High GARP expression is associated with pancreatic cancer and liver metastases from colorectal cancer. PMID: 26885615
    4. study showed that stimulated, human B lymphocytes produce active TGF-beta1 from surface GARP/latent TGF-beta1 complexes with isotype switching to IgA production. PMID: 28607112
    5. GARP plays an important role in the pathogenesis of atopic dermatitis. PMID: 27884290
    6. CD4(+) CD25(+) GARP(+) Treg cells are defective in dilated cardiomyopathy patients and GARP seems to be a better molecular definition of the regulatory phenotype. PMID: 28207945
    7. these results define the oncogenic effects of the GARP-TGFbeta axis in the tumor microenvironment PMID: 27913437
    8. LRRC32 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    9. GARP deficiency leads to accumulation of sphingolipid synthesis intermediates, changes in sterol distribution, and lysosomal dysfunction. PMID: 26357016
    10. since GARP functions as a transporter of transforming growth factor beta (TGFbeta), a cytokine with broad pleiotropic traits, GARP transcriptional attenuation by alternative promoters might provide a mechanism regulating peripheral TGFb PMID: 26584734
    11. GARP is regulated by miRNAs and controls latent TGF-beta1 production by human regulatory T cells. PMID: 24098777
    12. we investigated in detail miR-142-3 pregulation of GARP expression in regulatory CD25(+) CD4 T cells PMID: 23650616
    13. Findings support the idea that GARP is a new latent TGFbeta-binding protein that regulates the bioavailability of TGFbeta and provides a cell surface platform for alphaV integrin-dependent TGFbeta activation. PMID: 22278742
    14. There are 2 independent signals, one in C11orf30 and the other in LRRC32, that are strongly associated with serum IgE levels. C11orf30-LRRC32 region may represent a common locus for atopic diseases via pathways involved in regulation of serum IgE levels PMID: 22070912
    15. GARP is a key receptor controlling FOXP3 in T(reg) cells following T-cell activation in a positive feedback loop assisted by LGALS3 and LGMN PMID: 19453521
    16. the processing and expression of LRRC32 PMID: 21615933
    17. on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP) associated with asthma risk PMID: 21907864
    18. GARP is a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression PMID: 18628982
    19. Platelets and activated Tregs co-express latent TGF-beta and GARP on their membranes. PMID: 19651619
    20. Expression of GARP on activated regulatory T cells correlates with their suppressive capacity. PMID: 19666573
    21. Data show that latent TGF-beta, i.e. both LAP and mature TGF-beta, binds to GARP, which is present on the surface of stimulated Treg clones but not on Th clones. PMID: 19750484

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell surface.
  • 組織特異性：
    Preferentially expressed in regulatory T-cells (Tregs).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4161

    OMIM: 137207

    KEGG: hsa:2615

    STRING: 9606.ENSP00000260061

    UniGene: Hs.151641



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