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  4. STEAP1 (Vandortuzumab Biosimilar) Recombinant Monoclonal Antibody

STEAP1 (Vandortuzumab Biosimilar) Recombinant Monoclonal Antibody

  • 中文名稱：
    STEAP1 (Vandortuzumab Biosimilar) Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA890691MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    2410007B19Rik antibody; EC 1.16.1.- antibody; Metalloreductase STEAP1 antibody; MGC19484 antibody; PRSS 24 antibody; PRSS24 antibody; Six transmembrane epithelial antigen of prostate antibody; Six transmembrane epithelial antigen of the prostate 1 antibody; Six transmembrane epithelial antigen of the prostate antibody; Six-transmembrane epithelial antigen of prostate 1 antibody; STEA1_HUMAN antibody; STEAP 1 antibody; Steap antibody; STEAP1 antibody; Vandortuzumab
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human STEAP1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Human IgG1 kappa
  • 純化方式：
    Affinity-chromatography
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, FACS
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
  • 基因功能參考文獻：
    1. High STEAP1 expression is associated with prostate cancer. PMID: 29464393
    2. Data suggest a solid basis for further research into understanding how six-transmembrane epithelial antigen of prostate member 1 (STEAP1) activities may affect cancer progression. PMID: 27792302
    3. These findings highlight the ability of immuno-PET with (89)Zr-2109A to detect acute changes in STEAP1 expression PMID: 25453051
    4. Data indicate that six transmembrane epithelial antigen of the prostate 1 (STEAP1) is consistently overexpressed in malignant prostate tissue, namely adenocarcinoma and prostatic intraepithelial neoplasia (PIN) lesions. PMID: 24239460
    5. The findings provide evidence that STEAP1 is a biomarker of worse prognosis in prostate carcinomas patients. PMID: 24025158
    6. STEAP1 is down-regulated by dihydrotestosterone and estradiols in LNCaP cells and in rat prostate. PMID: 23060075
    7. A total of 62.3% of the Ewing's Sarcoma samples displayed detectable STEAP1 expression with predominant localization of the protein at the plasma membrane. PMID: 22317770
    8. STEAP1 is associated with the invasive behavior and oxidative stress phenotype of Ewing tumors, an unanticipated oncogenic function of STEAP1. PMID: 22080479
    9. STEAP1 overexpression predicts improved outcome of Ewing's sarcoma patients, possibly due to enhanced sensitivity towards ROS-generating chemotherapeutics. PMID: 22317770
    10. EWS-FLI1 mediated overexpression of STEAP1 increases the invasiveness and oxidative stress levels of Ewing tumor cells. PMID: 22080479
    11. Data suggest that zoledronic acid may affect cancer cells also by targeting the gene expression of STEAP. PMID: 19915386
    12. Peptide STEAP-292.2L (MLAVFLPIV) may have potential as an antitumor peptide vaccine. PMID: 15958640
    13. STEAP mRNA is used here as a marker to evaluate biological samples from individuals suspected of having cancers, and may provide prognostic information useful in defining appropriate therapeutic options. PMID: 18793824
    14. STEAP1 is over-expressed in breast cancer and down-regulated by 17beta-estradiol. PMID: 18958632
    15. STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice. PMID: 19196137

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  • 亞細胞定位：
    Endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    STEAP family
  • 組織特異性：
    Ubiquitously expressed. Highly expressed in prostate tumors.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11378

    OMIM: 604415

    KEGG: hsa:26872

    STRING: 9606.ENSP00000297205

    UniGene: Hs.61635



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