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  4. VSIR (PMC-309 Biosimilar) Recombinant Monoclonal Antibody

VSIR (PMC-309 Biosimilar) Recombinant Monoclonal Antibody

Sequence Pending
  • 貨號：
    CSB-RA884484MB3HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    VSIR (PMC-309 Biosimilar Antibody)重組單克隆抗體是一種專為科研用途開發的生物制劑，其核心成分為通過基因工程技術構建的重組單克隆抗體分子。該產品基于先進的重組DNA技術，在特定表達系統中進行高效表達與純化，確?？贵w結構的均一性和批次間的穩定性，為科研實驗提供可靠的物質基礎。 該抗體可作為重要的研究工具，廣泛應用于免疫學、細胞生物學及相關領域的基礎研究與應用探索。其作用靶點明確，能夠特異性識別并結合目標分子，為研究VSIR相關信號通路、受體-配體相互作用及免疫調節機制提供關鍵支持。通過特異性結合特性，可助力科研人員深入探究VSIR在免疫應答、炎癥反應及疾病發生發展中的生物學功能，為揭示相關生理病理過程提供實驗依據。 產品嚴格遵循科研級標準進行生產與質量控制，通過一系列嚴格的檢測手段，包括純度分析、活性驗證、內毒素檢測等，確保產品符合科研實驗的嚴謹性要求。其凍干粉劑型便于長期儲存與運輸，復溶后可直接用于細胞培養等多種實驗方法，為不同研究場景提供靈活的應用選擇。 作為科研用重組單克隆抗體，該產品為生命科學領域的研究者提供了高質量的實驗材料，有助于推動免疫學機制研究、疾病模型構建及潛在治療靶點的發現，為相關領域的科學創新與發展提供有力支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    VSIR antibody; C10orf54 antibody; SISP1 antibody; VISTA antibody; PP2135 antibody; UNQ730/PRO1412 antibody; V-type immunoglobulin domain-containing suppressor of T-cell activation antibody; Platelet receptor Gi24 antibody; Stress-induced secreted protein-1 antibody; Sisp-1 antibody; V-set domain-containing immunoregulatory receptor antibody; V-set immunoregulatory receptor antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human VSIR protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS,pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation.
  • 基因功能參考文獻：
    1. Data indicate that VISTA is predominantly expressed and up-regulated in the high-density infiltrated immune cells but minimal in pancreatic cancerous cells. PMID: 29771768
    2. High VISTA expression is associated with colorectal carcinoma. PMID: 30128738
    3. VISTA expression supports immune-complex inflammation in collagen antibody-induced arthritis and VISTA is expressed in human synovium PMID: 29216931
    4. This study is the first to describe the expression of VISTA-expressing lymphocytes in melanoma samples and in the context of acquired resistance to immune checkpoint inhibitors PMID: 28776578
    5. Taken together, the results indicated that the VISTA high and CD8 low group, as an immunosuppressive subgroup, might be associated with a poor prognosis in primary OSCC. These findings indicated that VISTA might be a potential immunotherapeutic target in OSCC treatment. PMID: 28236118
    6. this review describes the functions of VISTA in the context of cancer immunotherapy PMID: 28258694
    7. overexpression of the newly described co-stimulatory molecule, PD1 homologue (PD-1H) in human monocyte/macrophages is sufficient to induce spontaneous secretion of multiple cytokines. PMID: 25279955
    8. p53-induced expression of DD1alpha prevents persistence of cell corpses and ensures efficient generation of precise immune responses in mice. PMID: 26228159
    9. Results suggest that GI24 contributes to tumor-invasive growth in the collagen matrix by augmenting cell surface MT1-MMP. PMID: 20666777

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta
  • 數據庫鏈接：

    HGNC: 30085

    OMIM: 615608

    KEGG: hsa:64115

    STRING: 9606.ENSP00000378409

    UniGene: Hs.47382



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