PIK3R1
PIK3R1，全稱為磷脂酰肌醇3-激酶調(diào)節(jié)亞基1，常用別名是p85α。它是PI3K蛋白復(fù)合物的關(guān)鍵組成部分，與催化亞基協(xié)同工作，幫助細(xì)胞接收外界信號并傳遞到內(nèi)部，從而調(diào)控細(xì)胞的生長、分裂和存活狀態(tài)。
當(dāng)PIK3R1出現(xiàn)異常時，可能導(dǎo)致細(xì)胞信號傳遞紊亂，進而引發(fā)多種疾病：比如在乳腺癌、肺癌等惡性腫瘤中，它的突變或表達(dá)變化常與細(xì)胞不受控增殖相關(guān)；此外，它也參與代謝和免疫相關(guān)的生理過程，功能異常還可能和糖尿病、某些遺傳性免疫疾病存在關(guān)聯(lián)。目前，針對該蛋白相關(guān)的細(xì)胞信號調(diào)節(jié)，已有一些藥物處于研發(fā)或臨床試驗階段，試圖通過靶向調(diào)節(jié)其功能來治療相關(guān)疾病，但具體療效仍需進一步臨床驗證。
熱銷產(chǎn)品
PIK3R1 Recombinant Monoclonal Antibody (CSB-RA596783A0HU)
驗證數(shù)據(jù)
Flow cytometric analysis of PI3 Kinase p85 alpha expression in C2C12 cells using PI3 Kinase p85 alpha antibody. Green, isotype control; red, PI3 Kinase p85 alpha.
Immunocytochemical staining of C2C12 cells with PI3 Kinase p85 alpha antibody. Nuclei were stained blue with DAPI; PI3 Kinase p85 alpha was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
Western blotting analysis using PI3 Kinase p85 alpha antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with PI3 Kinase p85 alpha antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
PIK3R1 Antibody (CSB-PA018003LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA018003LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA018003LA01HU at dilution of 1:100
PIK3R1 Antibodies
PIK3R1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018003GA01HU | PIK3R1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA143555 | Phospho-PIK3R1 (Tyr607) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000712 | Phospho-PIK3R1 (Y607) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA003765 | PIK3R1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA003767 | PIK3R1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA080202 | PIK3R1 Antibody | Rat,Mouse | WB |
| CSB-PA080203 | PIK3R1 Antibody | Human | WB |
| CSB-PA080209 | PIK3R1 Antibody | Human | WB, IHC |
| CSB-PA797351 | PIK3R1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA018003LA01HU | PIK3R1 Antibody | Human | ELISA, IHC |
| CSB-PA018003LD01HU | PIK3R1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA018003LC01HU | PIK3R1 Antibody, FITC conjugated | Human | |
| CSB-PA018003LB01HU | PIK3R1 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA101461A0HU | PIK3R1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA596783A0HU | PIK3R1 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC, ICC |
PIK3R1 Proteins
PIK3R1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018003HU CSB-EP018003HU CSB-BP018003HU CSB-MP018003HU CSB-EP018003HU-B |
Recombinant Human Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PIK3R1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018003MO CSB-BP018003MO CSB-MP018003MO CSB-EP018003MO-B |
Recombinant Mouse Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PIK3R1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018003BO CSB-EP018003BO CSB-BP018003BO CSB-MP018003BO CSB-EP018003BO-B |
Recombinant Bovine Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PIK3R1 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP716062PYX CSB-EP716062PYX CSB-BP716062PYX CSB-MP716062PYX CSB-EP716062PYX-B |
Recombinant Pongo abelii Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PIK3R1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP720544RA CSB-EP720544RA CSB-BP720544RA CSB-MP720544RA CSB-EP720544RA-B |
Recombinant Rat Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
