ABHD5
ABHD5，全稱為α/β水解酶結(jié)構(gòu)域蛋白5，常用別名脂解調(diào)節(jié)蛋白。它是細(xì)胞內(nèi)脂質(zhì)代謝相關(guān)蛋白，主要表達(dá)于脂肪組織、肝臟等代謝活躍組織，參與脂質(zhì)分解、脂滴穩(wěn)態(tài)調(diào)控，與脂肪酶協(xié)同作用，維持機(jī)體脂質(zhì)代謝平衡，防止脂肪異常蓄積。 ABHD5功能缺陷或表達(dá)不足會(huì)導(dǎo)致脂質(zhì)代謝異常，引發(fā)先天性脂質(zhì)營(yíng)養(yǎng)不良、脂肪肝、肥胖等疾病；異常表達(dá)則與肺癌、肝癌等腫瘤相關(guān)，通過(guò)調(diào)節(jié)腫瘤脂質(zhì)代謝，促進(jìn)腫瘤增殖。目前ABHD5激活劑處于臨床前研究階段，通過(guò)改善脂質(zhì)分解功能，為脂質(zhì)代謝異常疾病及腫瘤提供治療方案。
熱銷產(chǎn)品
Recombinant Human 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5) (CSB-EP819884HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ABHD5 Recombinant Monoclonal Antibody (CSB-RA982153A0HU)
驗(yàn)證數(shù)據(jù)
Flow cytometric analysis of ABHD5 expression in C2C12 cells using ABHD5 antibody. Green, isotype control; red, ABHD5.
Immunocytochemical staining of C2C12 cells with ABHD5 antibody. Nuclei were stained blue with DAPI; ABHD5 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm.
Western blotting analysis using ABHD5 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ABHD5 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
ABHD5 Antibody (CSB-PA819884ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA819884ESR1HU at dilution of 1:100
ABHD5 Antibodies
ABHD5 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA001097GA01HU | ABHD5 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA819884ESR1HU | ABHD5 Antibody | Human | ELISA, IHC |
| CSB-PA149552 | ABHD5 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA072974 | ABHD5 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA819884HA01HU | ABHD5 Antibody | Human | ELISA, IF |
| CSB-PA819884HB01HU | ABHD5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA819884HD01HU | ABHD5 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA982153A0HU | ABHD5 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, FC, ICC |
| CSB-RA038671A0HU | ABHD5 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB |
ABHD5 Proteins
ABHD5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP819884HU CSB-BP819884HU CSB-MP819884HU CSB-EP819884HU-B |
Recombinant Human 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP819884HU | Recombinant Human 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5) | E.coli |
