ADCY10
ADCY10，全稱為腺苷酸環(huán)化酶10，常用別名是可溶性腺苷酸環(huán)化酶（sAC）。它和多數(shù)同類蛋白不同，不需要借助G蛋白就能發(fā)揮作用，主要負(fù)責(zé)在細(xì)胞內(nèi)生成環(huán)腺苷酸（cAMP）——這種分子是細(xì)胞內(nèi)重要的“信使”，能調(diào)節(jié)細(xì)胞的生長、代謝、應(yīng)激反應(yīng)等多種生理過程。
在疾病方面，sAC的活性異常與多種病癥相關(guān)：部分癌癥（如肝癌、結(jié)直腸癌）中它的表達(dá)量會升高，可能促進(jìn)腫瘤細(xì)胞的增殖和擴(kuò)散；一些炎癥性疾病（如哮喘、腸炎）里也能看到它的作用，它可能加重炎癥反應(yīng)。藥物研發(fā)上，目前已有針對sAC的抑制劑進(jìn)入研究階段，這些小分子藥物嘗試通過抑制其活性來控制相關(guān)疾病，不過大多還處于臨床試驗早期，尚未正式應(yīng)用于臨床治療。
熱銷產(chǎn)品
ADCY10 Antibody (CSB-PA839393LA01HU)
驗證數(shù)據(jù)
IHC image of CSB-PA839393LA01HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
ADCY10 Antibodies
ADCY10 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA839393LA01HU | ADCY10 Antibody | Human | ELISA, IHC |
| CSB-PA839393LC01HU | ADCY10 Antibody, FITC conjugated | Human |
ADCY10 Proteins
ADCY10 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP774729RB CSB-EP774729RB CSB-BP774729RB CSB-MP774729RB CSB-EP774729RB-B |
Recombinant Rabbit Adenylate cyclase type 10 (ADCY10), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ADCY10 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP804898MO CSB-BP804898MO CSB-MP804898MO CSB-EP804898MO-B |
Recombinant Mouse Adenylate cyclase type 10 (Adcy10), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ADCY10 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP839393HU CSB-EP839393HU CSB-BP839393HU CSB-MP839393HU CSB-EP839393HU-B |
Recombinant Human Adenylate cyclase type 10 (ADCY10), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
