AGPAT2
AGPAT2，全稱為1-酰基甘油-3-磷酸O-?；D移酶2，也常被稱作LPAAT-beta。它在人體脂質代謝中扮演關鍵角色，參與甘油三酯的合成過程——幫助將脂肪酸連接到甘油骨架上，為身體儲存能量提供重要物質基礎。AGPAT2功能因基因變異受損時，會引發先天性全身性脂肪營養不良1型（Berardinelli-Seip綜合征）。患者全身脂肪組織幾乎完全缺失，容易出現血糖升高、血脂異常、肝臟脂肪堆積等代謝問題，還常伴隨胰島素抵抗，增加糖尿病、心血管疾病的風險。目前針對該疾病尚無特效治療藥物，科研人員正探索通過調節脂質代謝相關途徑來緩解癥狀，比如嘗試使用改善胰島素敏感性或調節血脂的藥物，但這些方案仍處于研究階段，需更多臨床試驗驗證其安全性和有效性。
熱銷產品
AGPAT2 Antibody (CSB-PA001450ESR2HU)
驗證數據
Western blot
All lanes: AGPAT2 antibody at 1.09μg/ml + Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 31, 28 kDa
Observed band size: 31 kDa
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA001450ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA001450ESR2HU at dilution of 1:100
AGPAT2 Antibodies
AGPAT2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA101475 | AGPAT2 Antibody | Human | ELISA,WB |
| CSB-PA001450ESR2HU | AGPAT2 Antibody | Human | ELISA, WB, IHC |
AGPAT2 Proteins
AGPAT2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP001450HU1 CSB-EP001450HU1 CSB-BP001450HU1 CSB-MP001450HU1 CSB-EP001450HU1-B |
Recombinant Human 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF001450HU | Recombinant Human 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) | in vitro E.coli expression system |
AGPAT2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP814318MO1 CSB-EP814318MO1 CSB-BP814318MO1 CSB-MP814318MO1 CSB-EP814318MO1-B |
Recombinant Mouse 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (Agpat2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF814318MO | Recombinant Mouse 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (Agpat2) | in vitro E.coli expression system |
