APEH
APEH，即酰肽水解酶，常見別名包括酰肽酶A、丙氨酸氨基肽酶和OMPH。它廣泛分布于人體大腦神經元、肝臟、腎臟等組織，主要負責分解細胞內N端帶有酰基修飾的肽鏈，維持蛋白質組的動態平衡。在大腦中，APEH能參與清除異常折疊的肽類物質，比如與阿爾茨海默病相關的β淀粉樣肽片段；活性降低時，異常肽積累可能加重神經損傷，提升活性則有望緩解病理變化。目前，針對該蛋白的小分子調節劑研發處于早期階段，部分化合物已在細胞模型中顯示增強功能的效果，或成為神經退行性疾病的潛在治療藥物。此外，其表達水平變化還與某些肝臟代謝紊亂疾病相關，可作為輔助診斷的生物標志物。
熱銷產品
Recombinant Human Acylamino-acid-releasing enzyme (APEH) (CSB-EP001899HUc7)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
APEH Antibody (CSB-PA001899LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA001899LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001899LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA001899LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Western Blot
Positive WB detected in: Hela whole cell lysate
All lanes: APEH antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 82 kDa
Observed band size: 82 kDa
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA001899LA01HU at dilution of 1:100
Human Acylamino-acid-releasing enzyme(APEH) ELISA kit (CSB-EL001899HU)
驗證數據
貨號：CSB-EL001899HU
規格：96T/48T
靈敏度：7.81 pg/mL
檢測范圍：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
APEH Antibodies
APEH for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA001899GA01HU | APEH Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA194613 | APEH Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA001899LA01HU | APEH Antibody | Human | ELISA, WB, IHC, IF |
APEH Proteins
APEH Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP001899HU CSB-BP001899HU CSB-EP001899HU-B |
Recombinant Human Acylamino-acid-releasing enzyme (APEH) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP001899HU | Recombinant Human Acylamino-acid-releasing enzyme (APEH) | E.coli |
| CSB-EP001899HUc7 | Recombinant Human Acylamino-acid-releasing enzyme (APEH) | E.coli |
APEH ELISA Kit
APEH ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL001899HU | Human Acylamino-acid-releasing enzyme(APEH) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 7.81 pg/mL |
