ASAH1
ASAH1，全稱為酸性神經酰胺酶，常見別名包括AC、酸性鞘磷脂酶相關蛋白等。它主要存在于細胞的溶酶體中，負責分解神經酰胺這種脂質分子，生成鞘氨醇和游離脂肪酸，這一過程對維持細胞內脂質穩態至關重要，影響著細胞生長、分化與凋亡等多種生理活動。
ASAH1功能異常時，可能引發脂質代謝紊亂相關疾病。例如尼曼匹克病A型和B型，就是因ASAH1活性不足，導致神經酰胺在細胞內堆積，進而造成肝脾腫大、神經系統損傷等癥狀。此外，它還與炎癥性疾病及部分腫瘤的進展相關，其表達水平的變化可能影響腫瘤細胞的增殖與轉移。目前針對ASAH1的藥物研發正逐步推進，一些調節其活性的小分子化合物已進入臨床前研究，有望為相關疾病的治療提供新方向。
熱銷產品
Recombinant Human Acid ceramidase (ASAH1) (CSB-EP619774HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ASAH1 Antibody (CSB-PA619774ESR1HU)
驗證數據
Western blot
All lanes: Acid ceramidase antibody at 6μg/ml + Mouse heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 45, 47 kDa
Observed band size: 45 kDa
Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA619774ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA619774ESR1HU at dilution of 1:100
ASAH1 Antibodies
ASAH1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA002169GA01HU | ASAH1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA619774ESR2HU | ASAH1 Antibody | Human | ELISA, IHC |
| CSB-PA619774ESR1HU | ASAH1 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA578122 | ASAH1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA208943 | ASAH1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA619774LA01HU | ASAH1 Antibody | Human | ELISA, WB, IHC |
ASAH1 Proteins
ASAH1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP619774HU CSB-BP619774HU CSB-MP619774HU CSB-EP619774HU-B |
Recombinant Human Acid ceramidase (ASAH1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP619774HU | Recombinant Human Acid ceramidase (ASAH1) | E.coli |
ASAH1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP895296MO CSB-BP895296MO CSB-MP895296MO CSB-EP895296MO-B |
Recombinant Mouse Acid ceramidase (Asah1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP895296MO | Recombinant Mouse Acid ceramidase (Asah1), partial | E.coli |
| CSB-CF895296MO | Recombinant Mouse Acid ceramidase (Asah1), partial | in vitro E.coli expression system |
