ASCL1
ASCL1，全稱為Achaete-scute同源物1，常見別名包括ASH1。它是神經發育過程中的核心調控蛋白之一，在胚胎階段就能引導未分化的干細胞向神經細胞方向分化，對大腦神經元的形成和神經系統的功能維持至關重要。此外，它在神經內分泌細胞的分化中也扮演著關鍵角色，確保相關組織的正常發育。
在病理狀態下，ASCL1異常表達與小細胞肺癌關系密切——這類腫瘤中它的高表達往往伴隨腫瘤細胞的快速增殖和侵襲能力增強，是臨床識別小細胞肺癌的重要生物標志物，也與患者的預后密切相關。目前針對該蛋白的靶向治療研究正在推進，科研人員嘗試通過阻斷其活性來抑制腫瘤生長，部分候選藥物已進入早期臨床試驗階段，為小細胞肺癌的精準治療帶來了新的希望。
熱銷產品
Recombinant Human Achaete-scute homolog 1 (ASCL1) (CSB-EP002199HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ASCL1 Antibody (CSB-PA002199LA01HU)
驗證數據
Western Blot
Positive WB detected in: Rat brain tissue
All lanes: ASCL1 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 26 kDa
Observed band size: 26 kDa
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA002199LA01HU at dilution of 1:100
ASCL1 Antibodies
ASCL1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA010194 | ASCL1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA796684 | ASCL1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA298683 | ASCL1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA677053 | ASCL1 Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA002199LA01HU | ASCL1 Antibody | Human, Rat | ELISA, WB, IHC |
| CSB-PA002199LB01HU | ASCL1 Antibody, HRP conjugated | Human | ELISA |
ASCL1 Proteins
ASCL1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP002199RA CSB-EP002199RA CSB-BP002199RA CSB-MP002199RA CSB-EP002199RA-B |
Recombinant Rat Achaete-scute homolog 1 (Ascl1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ASCL1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP002199HU CSB-BP002199HU CSB-MP002199HU CSB-EP002199HU-B |
Recombinant Human Achaete-scute homolog 1 (ASCL1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP002199HU | Recombinant Human Achaete-scute homolog 1 (ASCL1) | E.coli |
