BLM
BLM，全稱為布盧姆綜合征解旋酶，常用別名是RECQL3。它主要分布在細胞核內，參與DNA復制、損傷修復與同源重組過程，能夠維持染色體結構穩定，避免基因序列發生錯誤或斷裂，對細胞正常分裂與遺傳信息穩定傳遞至關重要。
BLM蛋白功能缺陷會直接導致布盧姆綜合征，患者表現為身材矮小、日光敏感、免疫異常，并顯著提高多種惡性腫瘤的發生風險。此外，其異常表達也與部分散發性腫瘤的進展相關。目前圍繞BLM的靶向研究主要集中在基因修復與合成致死策略，相關小分子調節劑與基因治療方向均處于臨床前探索階段，為遺傳性綜合征及相關腫瘤治療提供了潛在方向。
熱銷產品
Recombinant Human RecQ-like DNA helicase BLM (BLM), partial (CSB-MP002715HU1)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The purity of BLM was greater than 90% as determined by SEC-HPLC
BLM Antibodies
BLM for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA188391 | Phospho-BLM (Thr99) Antibody | Human | ELISA,WB,IHC |
| CSB-PA050012 | Phospho-BLM (T99) Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA050013 | BLM Antibody | Human | IHC, IF, ELISA |
BLM Proteins
BLM Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP002715HU CSB-BP002715HU CSB-MP002715HU CSB-EP002715HU-B |
Recombinant Human RecQ-like DNA helicase BLM (BLM), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP002715HU | Recombinant Human RecQ-like DNA helicase BLM (BLM), partial | E.coli |
| CSB-MP002715HU1 | Recombinant Human RecQ-like DNA helicase BLM (BLM), partial | Mammalian cell |
| CSB-EP002715HU1(M) | Recombinant Human RecQ-like DNA helicase BLM (BLM) (K24A), partial | E.coli |
| CSB-EP002715HU1 | Recombinant Human RecQ-like DNA helicase BLM (BLM), partial | E.coli |
| CSB-MP002715HU1(M) | Recombinant Human RecQ-like DNA helicase BLM (BLM) (K24A),partial | Mammalian cell |
| CSB-MP002715HU1(M)d7 | Recombinant Human RecQ-like DNA helicase BLM (BLM) (K24A), partial | Mammalian cell |
| CSB-MP002715HU1d7 | Recombinant Human RecQ-like DNA helicase BLM (BLM), partial | Mammalian cell |
